Frambesia
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  Frambesia



Frambesia

   Also known as yaws, frambesia is a common chronic infectious disease that occurs mainly in the warm humid regions of the tropics with characteristic bumps on the skin of the face, hands, feet and genital area. Almost all cases of yaws are in children under 15 years of age.

RELATED TERMS
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Yaws
An infectious nonvenereal disease caused by a spirochete, Treponema pertenue. Mainly found in humid, equatorial regions. Symptoms include febrile disturbances, rheumatism, eruption of tubercles with a caseous crust on hands, feet, face and external genitals. Yaws is also known as: bouba, frambesia, tropica, parangi.

Frambesia
Also known as yaws, frambesia is a common chronic infectious disease that occurs mainly in the warm humid regions of the tropics with characteristic bumps on the skin of the face, hands, feet and genital area. Almost all cases of yaws are in children under 15 years of age.

Chronic
Ongoing or recurring. Chronic medical conditions include diabetes, epilepsy, and chronic fatigue syndrome.

Disease
Illness or sickness often characterized by typical patient problems (symptoms) and physical findings (signs). Disruption sequence: The events that occur when a fetus that is developing normally is subjected to a destructive agent such as the rubella (German measles) virus.

Skin
Skin is an organ of the integumentary system; which is composed of a layer of tissues that protect underlying muscles and organs. Skin is used for insulation, vitamin D production, sensation, and excretion (through sweat).

Face
The anterior portion of the head that includes the skin, muscles, and structures of the forehead, eyes, nose, mouth, cheeks, and jaw.

Feet
The plural of foot, both an anatomic structure and a unit of measure. As an anatomic structure, the foot is the end of the leg on which a person normally stands and walks. The foot is a particularly complex structure made up of dozens of bones that work together with muscles and tendons to execute precise movements. The bones of the foot include the 10 metatarsal bones and the 28 phalanges (toe bones).

Genital
Having to do with the sex organs.



SIMILAR TERMS
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Frambesias
A systemic non-venereal infection of the tropics caused by Treponema pallidum subspecies pertenue.

Frame Shift Mutation
A type of mutation in which a number of nucleotides not divisible by three is deleted from or inserted into a coding sequence, thereby causing an alteration in the reading frame of the entire sequence downstream of the mutation. These mutations may be induced by certain types of mutagens or may occur spontaneously.

Frame Shift Mutations
A type of mutation in which a number of nucleotides not divisible by three is deleted from or inserted into a coding sequence, thereby causing an alteration in the reading frame of the entire sequence downstream of the mutation. These mutations may be induced by certain types of mutagens or may occur spontaneously.

Frame Shift, Ribosomal
A directed change in translational reading frame that allows the production of a single protein from two or more overlapping genes. The process is programmed by the nucleotide sequence of the mRNA and is sometimes also affected by the secondary or tertiary mRNA structure. It has been described mainly in viruses (especially retroviruses), retrotransposons, and bacterial insertion elements but also in some cellular genes.

Frame Shifting, Ribosomal
A directed change in translational reading frame that allows the production of a single protein from two or more overlapping genes. The process is programmed by the nucleotide sequence of the mRNA and is sometimes also affected by the secondary or tertiary mRNA structure. It has been described mainly in viruses (especially retroviruses), retrotransposons, and bacterial insertion elements but also in some cellular genes.

Frame Shifts, Ribosomal
A directed change in translational reading frame that allows the production of a single protein from two or more overlapping genes. The process is programmed by the nucleotide sequence of the mRNA and is sometimes also affected by the secondary or tertiary mRNA structure. It has been described mainly in viruses (especially retroviruses), retrotransposons, and bacterial insertion elements but also in some cellular genes.

Frame, Open Reading
Reading frames where successive nucleotide triplets can be read as codons specifying amino acids and where the sequence of these triplets is not interrupted by stop codons.

Frames, Open Reading
Reading frames where successive nucleotide triplets can be read as codons specifying amino acids and where the sequence of these triplets is not interrupted by stop codons.

Frameshift Mutation
A type of mutation in which a number of nucleotides not divisible by three is deleted from or inserted into a coding sequence, thereby causing an alteration in the reading frame of the entire sequence downstream of the mutation. These mutations may be induced by certain types of mutagens or may occur spontaneously.

Frameshift Mutations
A type of mutation in which a number of nucleotides not divisible by three is deleted from or inserted into a coding sequence, thereby causing an alteration in the reading frame of the entire sequence downstream of the mutation. These mutations may be induced by certain types of mutagens or may occur spontaneously.

Frameshift Suppressor Gene
Genes that have a suppressor allele or suppressor mutation (SUPPRESSION, GENETIC) which cancels the effect of a previous mutation, enabling the wild-type phenotype to be maintained or partially restored.

Frameshift Suppressor Genes
Genes that have a suppressor allele or suppressor mutation (SUPPRESSION, GENETIC) which cancels the effect of a previous mutation, enabling the wild-type phenotype to be maintained or partially restored.

Frameshift, Ribosomal
A directed change in translational reading frame that allows the production of a single protein from two or more overlapping genes. The process is programmed by the nucleotide sequence of the mRNA and is sometimes also affected by the secondary or tertiary mRNA structure. It has been described mainly in viruses (especially retroviruses), retrotransposons, and bacterial insertion elements but also in some cellular genes.

Frameshifting, Ribosomal
A directed change in translational reading frame that allows the production of a single protein from two or more overlapping genes. The process is programmed by the nucleotide sequence of the mRNA and is sometimes also affected by the secondary or tertiary mRNA structure. It has been described mainly in viruses (especially retroviruses), retrotransposons, and bacterial insertion elements but also in some cellular genes.

Frameshifting, Translational
A directed change in translational reading frame that allows the production of a single protein from two or more overlapping genes. The process is programmed by the nucleotide sequence of the mRNA and is sometimes also affected by the secondary or tertiary mRNA structure. It has been described mainly in viruses (especially retroviruses), retrotransposons, and bacterial insertion elements but also in some cellular genes.

Frameshifts, Ribosomal
A directed change in translational reading frame that allows the production of a single protein from two or more overlapping genes. The process is programmed by the nucleotide sequence of the mRNA and is sometimes also affected by the secondary or tertiary mRNA structure. It has been described mainly in viruses (especially retroviruses), retrotransposons, and bacterial insertion elements but also in some cellular genes.

Framework Region
That region of the immunoglobulin (antibody) molecule that varies in its amino acid sequence and composition, confers the antigenic specificity, and is thought to comprise the binding site for the antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions.

Framingham Study
A landmark study begun in 1948 in which some 12,000 residents of the town of Framingham, Massachusetts were enrolled in a study designed to gather medical data and, more recently, DNA samples. The participants in the Framingham study came in for regular medical exams and provided the information that researchers have requested. This extraordinary longitudinal (long-term) study has yielded a vast set of data from which invaluable health information has been extracted.

Framycetin
A component of NEOMYCIN that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed)

Framycetin Sulfate
A component of NEOMYCIN that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed)



PREVIOUS AND NEXT TERMS
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Fractured hip
Broken bone in the hip, a key health problem among the elderly, usually due to a fall or other kind of trauma involving direct impact to the hip bone which has been weakened by osteoporosis. The part of the hip most often broken is the greater trochanter of the femur.

Fragile site
A term devised in 1969 by Frederick Hecht to denote a heritable point on a chromosome where gaps and breaks tend to occur.

Fragile X chromosome
An X chromosome with a heritable fragile site associated with a frequent form of mental retardation -- the fragile X syndrome.

Fragile X syndrome
One of the most common causes of inherited mental retardation and neuropsychiatric disease in human beings, affects as many as one in 2000 males and one in 4000 females. The syndrome is also known as FRAXA (the fragile X chromosome itself) and as the Martin-Bell syndrome. However, the preferred name is fragile X syndrome.

Frailty syndrome
A condition, seen particularly in older patients, characterized by low functional reserve, easy tiring, decrease of libido, mood disturbance, accelerated osteoporosis, decreased muscle strength, and high susceptibility to disease. People with the frailty syndrome may take a sudden turn for the worse and die. However, the frailty syndrome may sometimes be reversible.

Frambesia

Framingham Study
A landmark study begun in 1948 in which some 12,000 residents of the town of Framingham, Massachusetts were enrolled in a study designed to gather medical data and, more recently, DNA samples. The participants in the Framingham study came in for regular medical exams and provided the information that researchers have requested. This extraordinary longitudinal (long-term) study has yielded a vast set of data from which invaluable health information has been extracted.

Frankenfood
Perjorative term for genetically modified food whether it be derived from genetically engineered plants or animals.

Frasier syndrome
A condition characterized by the presence of an XY sex chromosome constitution and undermasculinized external genitalia that may range from ambiguous in appearance to normal-looking female genitalia. There is also kidney disease (glomerulosclerosis) and gonadal tumors (gonadoblastoma). Frasier syndrome is caused by point mutations in the WT1 gene (in the intron 9 donor splice site).

Fraternal twin
A twin who have shared a common uterine environment with its sibling. Fraternal twins are due to the fertilization of two different ova by different sperm. Fraternal twins are also called dizygotic twins.

Freckle
A flat circular spot on the skin about the size of the head of a nail that develops after repeated exposure to sunlight, particularly in someone of fair complexion. Freckles may be red, yellow, tan, light-brown, brown, or black. They are always darker than the skin around them since they are due to deposits of the dark melanin, a dark pigment.

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