Zellweger Syndrome
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  Zellweger Syndrome



Zellweger Syndrome

    Zellweger Syndrome is a rare, autosomal recessive congenital syndrome of multiple abnormalities. Some of the principal characteristics are cerebral dysfunction, defective myelinization, craniofacial abnormalities, renal cysts, hepatomegaly, and biliary dysgenesis. Absence of liver and kidney peroxisomes is the underlying basic defect.

RELATED TERMS
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Syndrome
A grouping of signs and symptoms, based on their frequent co-occurrence, that may suggest a common underlying pathogenesis, course, familial pattern, or treatment selection.

Autosomal
"Pertaining to a chromosome that is not a sex chromosome; relating to any one of the chromosomes save the sex chromosomes. People normally have 22 pairs of autosomes (44 autosomes) in each cell together with two sex chromosomes (X and Y in the male and XX in the female). "

Congenital
Present at birth.

Cerebral
Referring to the cerebrum.

Dysfunction
Difficult function or abnormal function.

Renal
Pertains to kidneys.

Cysts
Any closed cavity or sac, normal or abnormal, lined by epithelium, and especially one that contains a liquid or semisolid material. (Dorland, 27th ed)

Hepatomegaly
Enlargement of the liver.

Biliary
Having to do with the gallbladder, bile ducts, or bile. The biliary system itself consists of the gallbladder and bile ducts and, of course, the bile.

Dysgenesis
Defective embryonic development.

Liver
The largest organ in the body. The liver carries out many important functions, such as making bile, changing food into energy, and cleaning alcohol and poisons from the blood.

Kidney
One of the paired organs that excrete urine. The kidneys are bean-shaped organs (about 11 cm long, 5 cm wide, and 3 cm thick) lying on either side of the vertebral column, posterior to the peritoneum, about opposite the twelfth thoracic and first three lumbar vertebrae.



SIMILAR TERMS
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PREVIOUS AND NEXT TERMS
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Zygote
A fertilized egg. Or the diploid cell that results from the joining of two haploid gametes (sperm and egg) during sexual reproduction, that will cleave to form an embryo.

Zoster
Acute inflammatory disease with vesicles grouped in the course of cutaneous nerves, as in herpes zoster.

Zoloft
A commercial name for sertraline hydrochloride, an orally administered antidepressant of the selective serotonin reuptake inhibitor (SSRI) type. Sertraline is used medically mainly to treat the symptoms of depression.

Zithromax
An antibiotic approved for the treatment of chlamydia and bacterial infections of the skin and respiratory tract. It may also have activity against MAC, toxoplasmosis and cryptosporidiosis.

Zellweger Syndrome

Zenker's diverticulum
Pouches in the esophagus from increased pressure in and around the esophagus.

Zygote intrafallopian transfer (ZIFT)
Method of treating infertility by removing eggs from a woman's ovaries, fertilizing them in the laboratory with sperm from her partner or a donor, and inserting one or more of the fertilized eggs into one of her fallopian tubes.

Zollinger-ellison syndrome
A group of symptoms that occur when a tumor called a gastrinoma forms in the pancreas. The tumor, which may cause cancer, releases large amounts of the hormone gastrin. The gastrin causes too much acid in the duodenum, resulting in ulcers, bleeding, and perforation.

Zeitgeist
The general intellectual and cultural climate of taste characteristic of an era.

Zoophilia
One of the paraphilias, characterized by marked distress over, or acting on, urges to indulge in sexual activity that involves animals.

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