Vaccinia
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  Vaccinia



Vaccinia

   An infection, primarily local and limited to the site of inoculation, induced in man by inoculation with the vaccinia (coxpox) virus in order to confer resistance to smallpox (variola). On about the third day after vaccination, papules form at the site of inoculation which become transformed into umbilicated vesicles and later pustules; they then dry up, and the scab falls off on about the 21st day, leaving a pitted scar; in some cases there are more or less marked constitutional disturbances.

RELATED TERMS
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Infection
Anything that invades the body and reproduces. Infections can be bacteria, protozoa, fungi, or viruses. Bacteria and fungi are one celled creatures that cause many infections including strep throat, bladder infections, and some lung infections. Fungi cause “athlete’s foot” and thrush, an infection in the mouth. Protozoa are small organisms with many cells that can cause infections in the guts or in the lungs. Most healthy people do not get protozoal infections, but people with suppressed immune systems can. Viruses are not really organisms; they are tiny particles that can live only inside another cell. They reproduce by taking over a cell and causing that cell to make more virus particles, rather than doing what the cell is supposed to do. Viruses cause most colds and flu cases.

Local
In the area of the tumor; confined to one specific area.

Inoculation
The injection of a disease agent into the body to cause a mild form of the disease and build immunity.

Vaccinia
An infection, primarily local and limited to the site of inoculation, induced in man by inoculation with the vaccinia (coxpox) virus in order to confer resistance to smallpox (variola). On about the third day after vaccination, papules form at the site of inoculation which become transformed into umbilicated vesicles and later pustules; they then dry up, and the scab falls off on about the 21st day, leaving a pitted scar; in some cases there are more or less marked constitutional disturbances.

Virus
Ultramicroscopic infectious agent that replicates itself only within cells of living hosts; many are pathogenic; a piece of nucleic acid (DNA or RNA) wrapped in a thin coat of protein.

Smallpox
A viral disease that was once highly contagious. Characterized by high fever, vomiting, and blisters and sores on the skin. Vaccination has eliminated this disease.

Vaccination
Originally referred to immunization against smallpox with the less virulent cowpox (vaccinia) virus; more loosely used for any immunization against a pathogen.

Papules
A small circumscribed, solid, elevated lesion of the skin.

Umbilicated
Marked by depressed spots resembling the umbilicus.



SIMILAR TERMS
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Vaccination
Originally referred to immunization against smallpox with the less virulent cowpox (vaccinia) virus; more loosely used for any immunization against a pathogen.

Vaccine
A preparation, often of living weakened microorganisms, that is introduced into the body to produce immunity to a specific disease by causing the formation of antibodies.



PREVIOUS AND NEXT TERMS
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Vesicle
1. A small, sac-like cavity. 2. A blister.

Vesicourethral reflux
An abnormal condition that allows urine to flow from the bladder back into a ureter.

Viscera
The large internal organs.

Vision
The sense of sight.

Vascularity
The blood supply of a tumor.

Vaccinia

Variola
Syn: smallpox.

Variolation
The historical practice of inducing immunity against smallpox by "scratching" the skin with the purulency from smallpox skin pustules. The first inoculation for smallpox is said to have been done in China about 1022 B.C.

Viremia
The presence of virus in the bloodstream.

Virion
The complete virus particle that is structurally intact and infectious.

Vermiculite
A lightweight and highly water-absorbent micaceous mineral that is sometimes used as a substitute for asbestos.

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