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Osteogenesis imperfecta
Osteogenesis imperfecta An inherited disorder of collagen which takes several forms. Premature osteoarthritis, blue sclerae, hypermobility and bone fragility may be features of the condition.
RELATED TERMS--------------------------------------
Collagen
At a microscopic level, this is the 'skeleton' of most tissues in the body.
Premature
The term used to describe babies born before 37 weeks of gestation. Fewer than 10 percent of babies arrive this early.
Osteoarthritis
Degenerative disorder of joints, most often from disease in the spine and in the weight bearing joints (knees and hips). Normally seen with aging, but can occur prematurely due to various reasons, for instance after an injury to a joint. Also known as degenerative joint disease, it can cause joint pain, loss of function, reduced joint motion, and deformity.
Bone
Bone refers either to a hardened connective tissue or to one of the individual structures, or organs, into which it is formed, found in many animals. Bones support body structures, protect internal organs, and (in conjunction with muscles) facilitate movement; are also involved with cell formation, calcium metabolism, and mineral storage. The bones of an animal are, collectively, known as the skeleton.
Condition
The term "condition" has a number of biomedical meanings including the following: 1.An unhealthy state, such as in "this is a progressive condition." 2.A state of fitness, such as "getting into condition." 3.Something that is essential to the occurrence of something else; essentially a "precondition." 4.As a verb: to cause a change in something so that a response that was previously associated with a certain stimulus becomes associated with another stimulus; to condition a person, as in behavioral conditioning.
SIMILAR TERMS--------------------------------------
Osteitis condensans ilii
Sclerosis at the sacral side of the sacroiliac joint. Unknown aetiology. May be confused with sacroiliitis.
Osteitis deformans
Paget's disease of bone.
Osteitis fibrosa cystica
Bone disease which occurs in hyperparathyroidism. Excess fibrous tissue and osteoclasts are found in lesions which may become cystic ('Brown tumours').
Osteoarthritis
Degenerative disorder of joints, most often from disease in the spine and in the weight bearing joints (knees and hips). Normally seen with aging, but can occur prematurely due to various reasons, for instance after an injury to a joint. Also known as degenerative joint disease, it can cause joint pain, loss of function, reduced joint motion, and deformity.
Osteoarthrosis
Synonymous with 'osteoarthritis'.
Osteoblast
A type of bone cell characterized by its mobility and by its ability to produce bone matrix.
Osteoblastoma
Usually benign but occasionally malignant and metastasising tumour which occurs most commonly in the spine.
Osteocalcin
A protein found in young osteoblasts. (GLA protein, BGP) Serum level reflects rate of bone turnover.
Osteochondritis dissecans
A form of osteonecrosis in which a segment of bone and articular cartilage become demarcated and separate from the surrounding bone. Most commonly occurs in the knee.
Osteochondroma
A benign cartilage-tipped exostosis.
Osteoclast
Bone-resorbing cell.
Osteocyte
A type of bone cell characterized by its immobile location within a lacunus and by a reduced ability to produce bone matrix.
Osteogenic sarcoma
A malignant bone tumour which may occasionally arise in bone affected by Paget's disease.
Osteoid
Non-mineralised bone matrix.
Osteoid osteoma
A benign, osteoid-forming tumour. May be very painful, especially at night.
Osteolite
Osteolite is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): technetium tc-99m medronate kit.
Osteoma
Tumor of bone.
Osteomalacia
A disease of adults that is characterized by softening of the bones due to loss of bone mineral. Osteomalacia is characteristic of vitamin D deficiency in adults, while children with vitamin D deficiency suffer from rickets.
Osteomyelitis
Inflammation of bone.
Osteonecrosis
See 'Aseptic necrosis'.
Osteopathic Medical Center
The Osteopathic Medical Center is a hospital in Fort Worth, Texas, United States.
Osteopathic Medical Center of Texas
Osteopathic Medical Center of Texas is a hospital in Fort Worth, Texas (USA).
Osteopathic Medical Center-Philadelphia
The Osteopathic Medical Center-Philadelphia is a hospital in Philadelphia, Pennsylvania, United States.
Osteopathy
A system of therapy emphasizing primary medical care and the importance of body mechanics and manipulation to correct abnormalities.
Osteopenia
'Thin' bone due to osteomalacia or osteoporosis.
Osteophyte
Bony outgrowth seen at joint margin in osteoarthritis.
Osteoporosis
Break-down or disintegration of bone, resulting in diminished and porous bone mass. Osteoporosis can result from cancer (including breast cancer) that has spread to the bones), some cancer therapies, and estrogen deficiency (estrogen is an important participant in maintaining bone). Osteoporosis can cause pain, deformity (especially of the spine), pathologic fractures (fractures caused by weakened bone), or traumatic fractures (for example, wrist or hip fracture from a fall).
Osteopuncture
Form of acupuncture named by Ronald M. Lawrence, M.D. In osteopuncture, the needle penetrates the periosteum (the membrane that covers bones) and is usually electrified. The acupuncture points of osteopuncture do not correlate with "meridian points."
Osteosarcoma
Osteosarcoma is the most common primary malignant bone tumour, excluding myeloma and lymphoma. There is a predilection for the metaphyseal region of tubular long bones. 50% of cases occur around the knee. It is a cancer that usually affects the large bones of the arm or leg. It occurs most commonly in young people and affects more males than females. Also called osteogenic sarcoma.
Osteoscan
Osteoscan is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): technetium tc-99m etidronate kit.
Osteotomy
Operation to produce realignment of articular surfaces of a joint so as to exploit remaining undamaged cartilage.
PREVIOUS AND NEXT TERMS--------------------------------------
Osteocalcin
A protein found in young osteoblasts. (GLA protein, BGP) Serum level reflects rate of bone turnover.
Osteochondritis dissecans
A form of osteonecrosis in which a segment of bone and articular cartilage become demarcated and separate from the surrounding bone. Most commonly occurs in the knee.
Osteochondroma
A benign cartilage-tipped exostosis.
Osteoclast
Bone-resorbing cell.
Osteogenic sarcoma
A malignant bone tumour which may occasionally arise in bone affected by Paget's disease.
Osteogenesis imperfecta
Osteoid
Non-mineralised bone matrix.
Osteoid osteoma
A benign, osteoid-forming tumour. May be very painful, especially at night.
Osteonecrosis
See 'Aseptic necrosis'.
Osteopenia
'Thin' bone due to osteomalacia or osteoporosis.
Osteophyte
Bony outgrowth seen at joint margin in osteoarthritis.
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