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Impairment
Impairment A defect in organ function or whole body system, which may be temporary or permanent (eg. hemiplegia).
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Organ
A structural unit of an animal or plant that serves a specific function.
SIMILAR TERMS--------------------------------------
Impaction
Partial or completely unexposed tooth that is wedged against another tooth, bone, or soft tissue, precluding the eruption process
Impaired Glucose Tolerance (IGT)
Blood glucose (sugar) levels higher than normal but not high enough to be called diabetes. People with IGT may or may not develop diabetes. Other names (no longer used) for IGT are "borderline," "subclinical," "chemical," or "latent" diabetes.
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Intratumoral
Injection into a tumor (usually performed during surgery).
Intraventricular
Injection into a ventricle.
Irradiation
Treatment by ionizing radiation, such as x-rays, or radioactive sources such as radioactive iodine seeds. See radiation therapy.
Intern
A medical doctor who has completed medical school and is in the first year of additional training.
Immunoassay
Detection and assay of substances by serological (immunological) methods; in most applications the substance in question serves as antigen, both in antibody production and in measurement of antibody by the test substance.
Impairment
Inclusion criteria
The criteria that prospective subjects must meet to be eligible for participation in a study. See also exclusion criteria, admission criteria.
Independent Data Monitoring Committee (IDMC)
An independent committee that may be established by the study investigators to assess at intervals the progress of a ongoing blinded clinical trial, the safety data, and the critical efficacy endpoints, and to recommend whether to continue, modify or stop a trial. See also Data and Safety Monitoring Board, Monitoring Committee, Data Monitoring.
Institution (medical)
Any public or private entity or agency or medical or dental facility where clinical trials are conducted.
Instrumental activities of daily living (IADL)
Activities that are essential if a person is to live independently, eg. use of a telephone or public transportation, housework, cooking, financial management. See also activities of daily living (ADLs).
Intention-to-treat principle
The principle that asserts that the effect of a treatment policy can be best assessed by evaluating, on the basis of the intention to treat a subject (that is, the planned treatment regimen) rather than the actual treatment given. It has the consequence that subjects allocated to a treatment group should be followed up, assessed and analysed as members of that group irrespective of their compliance to the planned course of treatment.
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