Immune response (Ir) gene
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  Immune response (Ir) gene



Immune response (Ir) gene

    A gene controlling an immune response to a particular antigen; most genes of this type are in the MHC (major histocompatibility complex), and the term is rarely used to describe other types of Ir genes outside the MHC.

RELATED TERMS
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Gene
1. A unit of DNA that carries information for the biosynthesis of a specific product in the cell. 2. Ultimate unit by which inheritable characteristics are transmitted to succeeding generations in all living organisms. Genes are contained by, and arranged along the length of, the chromosome. The gene is composed of deoxyribonucleic acid (DNA). Each chromosome of each species has a definite number and arrangement of genes, which govern both the structure and metabolic functions of the cells and thus of the entire organism.

Immune
Resistant to a particular disease.

Antigen
A substance which, when present in animal tissue, stimulates the production of antibodies

Genes
Basic, functional units of heredity, each occupying a specific place on a chromosome.

Histocompatibility
Literally, the ability of tissues to get along; in immunology, it means identity in all transplantation antigens. These antigens, in turn, are collectively referred to as histocompatibility antigens.

MHC
Major Histocompatibility Complex. Region of chromosome 6 where HLA antigens are encoded.



SIMILAR TERMS
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Immune
Resistant to a particular disease.

Immune adherence
The adherence of particulate antigen coated with C3b to tissue having cells with C3b receptors.

Immune complex
Antigen bound to antibody.

Immune modulators
Substances that control the expression of the immune response.

Immune System
The body's natural defense system which produces antibodies to fight against foreign substances such as bacteria, viruses, toxins, and cancers.

Immunity
When a body's immune system helps fend off disease.

Immunization
Natural immunity provided by antibodies or induced immunity via inoculations.

Immuno globulin E
Immuno globulin E is the antibody produced in excess in allergic patients. IgE can be measured in a blood sample to determine if a person is allergic. Allergic people usually have high levels of IgE.

Immuno-Augmentative Clinic
The Immuno-Augmentative Clinic is a hospital in Freeport, Freeport, Bahamas.

Immunoassay
Detection and assay of substances by serological (immunological) methods; in most applications the substance in question serves as antigen, both in antibody production and in measurement of antibody by the test substance.

Immunofluorescence
Technique allowing the visualisation of a specific protein in cells or tissue sections (prepared from a biopsy) by binding a specific antibody conjugated to a fluorescent substrate.

Immunogen
A substance capable of inducing an immune response (as well as reacting with the products of an immune response). Compare with antigen.

Immunoglobulin
A serum protein involved in immunity. An antibody.

Immunoglobulin (Ig)
A general term for all antibody molecules. Each Ig unit is made up of two heavy chains and two light chains and has two antigen- binding sites.

Immunoglobulin E (IgE)
A type of antibody, formed to protect the body from infection, which attaches to mast cells in the respiratory and intestinal tracts and may cause allergic rhinitis, asthma, or eczema.

Immunoglobulins
Antibodies or proteins found in blood and tissue fluids produced by cells of the immune system to bind to substances in the body that are recognized as foreign antigens. Immunoglobulins sometimes bind to antigens that are not necessarily a threat to health and provoke an allergic reaction.

Immunohistochemical staining
A laboratory process of detecting an organism in tissues with antibodies. These antibodies are labeled with a compound that is seen as a colored deposit when viewed microscopically. In general, mesotheliomas require immunohistochemical confirmation before legal measures are initiated.

Immunology
The study of the body's natural defense system.

Immunosuppresive medications
Medications that suppress the body's immune system, used to minimize rejection of transplanted organs.

Immunosuppression
The artificial suppression of the immune response, usually through drugs, so that the body will not reject a transplanted organ or tissue. Drugs commonly used to suppress the immune system after transplant include prednisone, azathioprine (Imuran), mycophenolate mofetil (CellCept), and cyclosporine (Neoral).

Immunotherapy
Stimulating the body's natural defense system to attack and destroy cancers.

Immutable
Long-lasting and unchangeable.



PREVIOUS AND NEXT TERMS
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Idiotype
The combined antigenic determinants (idiotopes) found on antibodies of an individual that are directed at a particular antigen; such antigenic determinants are found only in the variable region.

Immediate-type hypersensitivity
Hypersensitivity tissue reaction occurring within minutes after the interaction of antigen and antibody.

Immune adherence
The adherence of particulate antigen coated with C3b to tissue having cells with C3b receptors.

Immune complex
Antigen bound to antibody.

Immune modulators
Substances that control the expression of the immune response.

Immune response (Ir) gene

Immunogen
A substance capable of inducing an immune response (as well as reacting with the products of an immune response). Compare with antigen.

Immunoglobulin (Ig)
A general term for all antibody molecules. Each Ig unit is made up of two heavy chains and two light chains and has two antigen- binding sites.

Interferon
A group of proteins having antiviral activity and capable of enhancing and modifying the immune response.

Internal image
A spatial configuration of the combining site of an anti-idiotype antibody which resembles the epitope to which the idiotype is directed.

Intron
A segment of DNA that does not code for protein; the intervening sequence of nucleotides between coding sequences or exons.

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