ICE Protease
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  ICE Protease



ICE Protease

   A member of the caspase family that is highly specific for interleukin-1beta (INTERLEUKIN-1). It plays a role in inflammation and mammalian APOPTOSIS. Interleukin-1beta converting enzyme is frequently abbreviated ICE. EC 3.4.22.36

RELATED TERMS
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Family
1. A group of individuals related by blood or marriage or by a feeling of closeness. 2. A biological classification of related plants or animals that is a division below the order and above the genus. 3. A group of genes related in structure and in function that descended from an ancestral gene. 4. A group of gene products similarly related in structure and function and of shared genetic descent. 5. Parents and their children. The most fundamental social group in humans.

Inflammation
A reaction to an injury to the body - by infection, chemicals or physical agents. The symptoms can be - depending on the location of the injury- redness, swelling, heat and pain. The purpose of the inflammation is to dilute and destroy the agent causing the inflammation. To do this, the immune system starts a cascade of actions that causes active cells to gather at the affected location. It is these cells and fluids that cause the redness, swelling, heat and pain.

APOPTOSIS
A form of cell death in which a programmed sequence of events leads to the elimination of cells without releasing harmful substances into the surrounding area. Apoptosis plays a crucial role in developing and maintaining health by eliminating old cells, unnecessary cells, and unhealthy cells. The human body replaces perhaps a million cells a second. Too little or too much apoptosis plays a role in a great many diseases. When programmed cell death does not work right, cells that should be eliminated may hang around and become immortal. For example, in cancer and leukemia. When apoptosis works overly well, it kills too many cells and inflicts grave tissue damage. This is the case in strokes and neurodegenerative disorders such as Alzheimer, Huntington and Parkinson diseases. Apoptosis is also called programmed cell death or cell suicide. Strictly speaking, the term apoptosis refers only to the structural changes cells go through, and programmed cell death refers to the complete underlying process, but the terms are often used interchangeably.

Enzyme
A cellular protein whose shape allows it to hold together several other molecules in close proximity to each other. In this way, enzymes are able to induce chemical reactions in other substances with little expenditure of energy and without being changed themselves. Basically, an enzyme acts as a catalyst.



SIMILAR TERMS
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Ice Cream
A frozen dairy food made from cream or butterfat, milk, sugar, and flavorings. Frozen custard and French-type ice creams also contain eggs.

Ice Creams
A frozen dairy food made from cream or butterfat, milk, sugar, and flavorings. Frozen custard and French-type ice creams also contain eggs.

Ice Hockey
A game in which two parties of players provided with curved or hooked sticks seek to drive a ball or puck through opposite goals. This applies to either ice hockey or field hockey.

Ice Hockeys
A game in which two parties of players provided with curved or hooked sticks seek to drive a ball or puck through opposite goals. This applies to either ice hockey or field hockey.

Ice Skating
Using ice skates, roller skates, or skateboards in racing or other competition or for recreation.

Ice Skatings
Using ice skates, roller skates, or skateboards in racing or other competition or for recreation.



PREVIOUS AND NEXT TERMS
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Icelandic Type Hereditary Cerebral Amyloid Angiopathy
A familial condition marked by the deposition of AMYLOID in the walls of small blood vessels in the cerebral cortex and meninges and characterized clinically by cerebral ischemia (see BRAIN ISCHEMIA), CEREBRAL INFARCTION, and CEREBRAL HEMORRHAGE..

Icelandic Type Amyloidosis
A familial condition marked by the deposition of AMYLOID in the walls of small blood vessels in the cerebral cortex and meninges and characterized clinically by cerebral ischemia (see BRAIN ISCHEMIA), CEREBRAL INFARCTION, and CEREBRAL HEMORRHAGE..

Ice Skatings
Using ice skates, roller skates, or skateboards in racing or other competition or for recreation.

Ice, Dry
A solid form of carbon dioxide used as a refrigerant.

Ice Skating
Using ice skates, roller skates, or skateboards in racing or other competition or for recreation.

ICE Protease

Ice Hockeys
A game in which two parties of players provided with curved or hooked sticks seek to drive a ball or puck through opposite goals. This applies to either ice hockey or field hockey.

Ice Hockey
A game in which two parties of players provided with curved or hooked sticks seek to drive a ball or puck through opposite goals. This applies to either ice hockey or field hockey.

Ice Creams
A frozen dairy food made from cream or butterfat, milk, sugar, and flavorings. Frozen custard and French-type ice creams also contain eggs.

Ice Cream
A frozen dairy food made from cream or butterfat, milk, sugar, and flavorings. Frozen custard and French-type ice creams also contain eggs.

ICDT
An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)

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