ICAM-1
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  ICAM-1



ICAM-1

   A cell-surface ligand with a role in leukocyte adhesion and inflammation. Its production is induced by gamma-interferon and it is required for neutrophil migration into inflamed tissue.

RELATED TERMS
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Leukocyte
White blood cell.

Adhesion
A band of scar tissue that joins normally separated internal body structures, most often after surgery, inflammation, or injury in the area.

Inflammation
A reaction to an injury to the body - by infection, chemicals or physical agents. The symptoms can be - depending on the location of the injury- redness, swelling, heat and pain. The purpose of the inflammation is to dilute and destroy the agent causing the inflammation. To do this, the immune system starts a cascade of actions that causes active cells to gather at the affected location. It is these cells and fluids that cause the redness, swelling, heat and pain.

Gamma-interferon
The major interferon produced by mitogenically or antigenically stimulated lymphocytes. It is structurally different from type I interferon (INTERFERON TYPE I) and its major activity is immunoregulation. It has been implicated in the expression of class II histocompatibility antigens in cells that do not normally produce them, leading to autoimmune disease.

Neutrophil
A mature white blood cell with a three- to five-lobed nucleus.

Tissue
Biological tissue is a group of cells that perform a similar function.The study of tissues is known as histology, or, in connection with disease, histopathology.The classical tools for studying the tissues are the wax block, the tissue stain, and the optical microscope, though developments in electron microscopy, immunofluorescence, and frozen sections have all added to the sum of knowledge in the last couple of decades.



SIMILAR TERMS
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PREVIOUS AND NEXT TERMS
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Ibuprofen, Potassium Salt
A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.

Ibuprofen, Sodium Salt
A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.

Ibuprofen, Magnesium Salt
A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.

Ibuprofen, Copper (2+) Salt
A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.

Ibuprofen, Calcium Salt
A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.

ICAM-1

IC50
The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.

IC3b
The larger fragment formed when C3 convertase splits C3 into C3a and C3b. In both the classical and alternate pathway, C3b participates in immune adherence and enhances phagocytosis. It also forms a cellular intermediate which continues the complement process. In the alternate pathways, C3b initiates a positive feedback activation of C3Pase.

Ibuprofen-Zinc
A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.

Ibuprofen, Zinc Salt
A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.

Ibuprofen, Aluminum Salt
A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.

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