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Hybridoma
Hybridoma A hybrid cell that results from the fusion of an antibody-secreting cell with a malignant cell; the progeny secrete antibody without stimulation and proliferate continuously both in vivo and in vitro.
RELATED TERMS--------------------------------------
Cell
Fundamental structural unit of all life. The cell consists primarily of an outer plasma membrane, which separates it from the environment; the genetic material (DNA), which encodes heritable information for the maintainance of life; and the cytoplasm, a heterogeneous assemblage of ions, molecules, and fluid.
Fusion
The union and integration of the instincts and drives so that they complement each other and help the organism to deal effectively with both internal needs and external demands.
Malignant
Cancerous; life-threatening.
Progeny
Children.
Secrete
To make and give off such as when the beta cells make insulin and then release it into the blood so that the other cells in the body can use it to turn glucose (sugar) into energy.
Antibody
An infection-fighting protein molecule in blood or secretory fluids that tags, neutralizes, and helps destroy pathogenic microorganisms (eg, bacteria, viruses) or toxins. Antibodies, known generally as immunoglobulins, are made and secreted by B-lymphocytes in response to stimulation by antigens. Each specific antibody binds only to the specific antigen that stimulated its production.
SIMILAR TERMS--------------------------------------
Hybridization
The mixing of two varieties, races, species, types or sub-types by cross breeding.
Hybristophilia
A paraphilia of the marauding/predatory type in which sexuoerotic arousal and facilitation and attainment of orgasm are responsive to and [dependent upon] {contingent on} being with a partner known to have committed an outrage or crime, such as rape, murder, or armed robbery [from Greek, hybridzein, to commit an outrage against someone + -philia]. The partner may have served a prison sentence as a convicted criminal, or may be instigated by the hybristophile to commit a crime and so be convicted and sent to prison.
PREVIOUS AND NEXT TERMS--------------------------------------
Helper T cells
A class of T cells which help trigger B cells to make antibody against thymus-dependent antigens. Helper T cells also help generate cytotoxic T cells.
Heterophile antigen
A cross-reacting antigen that appears in widely ranging species such as humans and bacteria.
Hinge region
A flexible, open segment of an antibody molecule that allows bending of the molecule. The hinge region is located between Fab and Fc and is susceptible to enzymatic cleavage.
Histocompatibility
Literally, the ability of tissues to get along; in immunology, it means identity in all transplantation antigens. These antigens, in turn, are collectively referred to as histocompatibility antigens.
Humoral immunity
Any immune reaction that can be transferred with immune serum is termed humoral immunity (as opposed to cell-mediated immunity). In general, this term refers to resistance that results from the presence of specific antibody.
Hybridoma
Hypersensitivity
State of reactivity to antigen that is greater than normal for the antigenic challenge; hypersensitivity is the same as allergy and denotes a deleterious outcome rather than a protective one.
Hypervariable regions
Portions of the light and heavy immunoglobulin chains that are highly variable in amino acid sequence from one immunoglobulin molecule to another, and that, together, constitute the antigen-binding site of an antibody molecule. Also, portions of the T-cell receptor which constitute the antigen-binding site.
Hallucinosis
A morbid condition, as in acute alcoholic hallucinosis, which is characterized by recurrent acute attacks marked by hallucinated auditory threats of persecution.
Haptic
Having to do with touch and the sense of touch. 2. Pertaining to the skin feelings and the sense of touch.
Hemisphere
As applied to the brain, either its left or its right half.
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