HACs (Chromosomes)
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  HACs (Chromosomes)



HACs (Chromosomes)

   DNA constructs that are composed of, at least, all elements, such as a REPLICATION ORIGIN; TELOMERE; and CENTROMERE, required for successful replication, propagation to and maintainance in progeny human cells. In addition, they are constructed to carry other sequences for analysis or gene transfer.

RELATED TERMS
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Elements
Substances that comprise all matter. Each element is made up of atoms that are identical in number of electrons and protons and in nuclear charge, but may differ in mass or number of neutrons.

CENTROMERE
The cinched "waist" of the chromosome essential for the division and the retention of the chromosome in the cell. The centromere is a uniquely specialized region of the chromosome to which spindle fibers attach during cell division.

Progeny
Children.

Analysis
A psychology term for processes used to gain understanding of complex emotional or behavioral issues.

Gene
1. A unit of DNA that carries information for the biosynthesis of a specific product in the cell. 2. Ultimate unit by which inheritable characteristics are transmitted to succeeding generations in all living organisms. Genes are contained by, and arranged along the length of, the chromosome. The gene is composed of deoxyribonucleic acid (DNA). Each chromosome of each species has a definite number and arrangement of genes, which govern both the structure and metabolic functions of the cells and thus of the entire organism.



SIMILAR TERMS
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Haematopinus
An order of insects comprising the sucking lice, which are blood-sucking ectoparasites of mammals. Recognized families include: Echionphthiriidae, Haematopinidae, and Pediculidae. The latter contains the medically important genera affecting humans: PEDICULUS and PHTHIRUS.

Haematobia irritans
A family of the order DIPTERA with over 700 species. Important species that may be mechanical vectors of disease include Musca domesticus (HOUSEFLIES), Musca autumnalis (face fly), Stomoxys calcitrans (stable fly), Haematobia irritans (horn fly) and Fannia spp.

Haemachatus
A genus of poisonous snakes of the subfamily Elapinae of the family ELAPIDAE. There are six recognized species, all inhabiting Africa except the Asiatic (Indian) cobra, Naja naja. Some species ""spit"" their venom into the eyes of their ""enemies"". So-called spitting cobras show a high degree of accuracy in aiming for the eyes. The ringhals, the most highly specialized of the spitting cobras, is limited to southern Africa. Its spray destroys eye tissue and can cause blindness; its bite can cause death. (Moore: Poisonous Snakes of the World, 1980, p80)

Haem Oxygenase
A mixed function oxidase enzyme which during hemoglobin catabolism catalyzes the degradation of heme to ferrous iron, carbon monoxide and biliverdin in the presence of molecular oxygen and reduced NADPH. The enzyme is induced by metals, particularly cobalt. EC 1.14.99.3.

Haemaccel
A 3.5 per cent colloidal solution containing urea-cross-linked polymerized peptides. It has a molecular weight of approximately 35,000 and is prepared from gelatin and electrolytes. The polymeric solution is used as a plasma expander.

HACs (Chromosomes)

Hafnium
Hafnium. A metal element of atomic number 72 and atomic weight 178.49, symbol Hf. (From Dorland, 28th ed)

Hageman Factor
Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease.

Haemosporina
An order of heteroxenous protozoa in which the macrogamete and microgamont develop independently. A conoid is usually absent.

Haemosporida
An order of heteroxenous protozoa in which the macrogamete and microgamont develop independently. A conoid is usually absent.

Haemorrhagic Adrenalitis, Meningococcal
A condition characterized by the abrupt onset of fever, petechiae, ARTHRALGIA, weakness, and myalgias followed by acute hemorrhagic necrosis of the adrenal glands and severe cardiovascular dysfunction. The syndrome is most often associated with meningococcal septicemia but may occur as a complication of sepsis caused by other organisms, including certain STREPTOCOCCUS species. This disorder may be associated with a prior history of SPLENECTOMY. (From J Emerg Med 1998 Jul-Aug;16(4):643-7)

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