Gag-fos-fox Fusion Proteins
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  Gag-fos-fox Fusion Proteins



Gag-fos-fox Fusion Proteins

   Transforming proteins coded by fos oncogenes. These proteins have been found in the Finkel-Biskis-Jinkins (FBJ-MSV) and Finkel-Biskis-Reilly (FBR-MSV) murine sarcoma viruses which induce osteogenic sarcomas in mice. The FBJ-MSV v-fos gene encodes a p55 kD protein and the FBR-MSV v-fos gene encodes a p75 kD fusion protein.

RELATED TERMS
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Oncogenes
Genes that promote normal cell division.

Sarcoma
A cancer of the bone, cartilage, fat, muscle, blood vessels or other connective or supportive tissue. A sarcoma is also defined as malignant mesenchymal neoplasm; e.g. osteosarcoma, (malignant mesenchymal neoplasm arising from bone tissue). Malignant tumor of soft tissue (tissue that connects, supports or surrounds other structures and organs of the body). Soft tissue includes muscles, tendons, fibrous tissues, fat, blood vessels and nerves.

Gene
1. A unit of DNA that carries information for the biosynthesis of a specific product in the cell. 2. Ultimate unit by which inheritable characteristics are transmitted to succeeding generations in all living organisms. Genes are contained by, and arranged along the length of, the chromosome. The gene is composed of deoxyribonucleic acid (DNA). Each chromosome of each species has a definite number and arrangement of genes, which govern both the structure and metabolic functions of the cells and thus of the entire organism.

Protein
Any of a group of complex organic compounds which contain carbon, hydrogen, oxygen, nitrogen, and usually sulfur, the characteristic element being nitrogen. Proteins, the principal constituents of the protoplasm of all cells, are of high molecular weight and consist essentially of combinations of a-amino acids in peptide linkages. Twenty different amino acids are commonly found in proteins, and each protein has a unique genetically defined amino acid sequence which determines its specific shape and function. Their roles include enzymatic catalysis, transport and storage, coordinated motion, nerve impulse generation and many others.

Fusion
The union and integration of the instincts and drives so that they complement each other and help the organism to deal effectively with both internal needs and external demands.



SIMILAR TERMS
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Gag-fes, p140
General name for the translation products of a fusion mRNA consisting of a gag gene and a viral oncogene (v-onc). These products are thought to have the ability to transform cells.

Gag-fes, pp85
General name for the translation products of a fusion mRNA consisting of a gag gene and a viral oncogene (v-onc). These products are thought to have the ability to transform cells.

Gag-fps, p140
General name for the translation products of a fusion mRNA consisting of a gag gene and a viral oncogene (v-onc). These products are thought to have the ability to transform cells.

Gag-jun Fusion Proteins
Transforming protein coded by jun oncogenes (GENES, JUN). This is a gag-onc fusion protein of about 65 kD derived from avian sarcoma virus. v-jun lacks a negative regulatory domain that regulates transcription in c-jun.

Gag-jun, p65
Transforming protein coded by jun oncogenes (GENES, JUN). This is a gag-onc fusion protein of about 65 kD derived from avian sarcoma virus. v-jun lacks a negative regulatory domain that regulates transcription in c-jun.

Gag-mos Fusion Proteins
Transforming proteins coded by mos oncogenes. The v-mos proteins were originally isolated from the Moloney murine sarcoma virus (Mo-MSV).

Gag-mos, p85
Transforming proteins coded by mos oncogenes. The v-mos proteins were originally isolated from the Moloney murine sarcoma virus (Mo-MSV).

Gag-myc Fused Protein p110
General name for the translation products of a fusion mRNA consisting of a gag gene and a viral oncogene (v-onc). These products are thought to have the ability to transform cells.

Gag-onc Fusion Proteins
General name for the translation products of a fusion mRNA consisting of a gag gene and a viral oncogene (v-onc). These products are thought to have the ability to transform cells.

Gag-pol Fused Protein
Polyprotein products of a fused portion of retroviral mRNA containing the gag and pol genes. The polyprotein is synthesized only five percent of the time since pol is out of frame with gag, and is generated by ribosomal frameshifting.

Gag-pol Fusion Proteins
Polyprotein products of a fused portion of retroviral mRNA containing the gag and pol genes. The polyprotein is synthesized only five percent of the time since pol is out of frame with gag, and is generated by ribosomal frameshifting.

Gag-pol Protein
Polyprotein products of a fused portion of retroviral mRNA containing the gag and pol genes. The polyprotein is synthesized only five percent of the time since pol is out of frame with gag, and is generated by ribosomal frameshifting.

Gag-pol-myc, p200
General name for the translation products of a fusion mRNA consisting of a gag gene and a viral oncogene (v-onc). These products are thought to have the ability to transform cells.

Gag-ros Fusion Proteins
General name for the translation products of a fusion mRNA consisting of a gag gene and a viral oncogene (v-onc). These products are thought to have the ability to transform cells.



PREVIOUS AND NEXT TERMS
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Gag-mos, p85
Transforming proteins coded by mos oncogenes. The v-mos proteins were originally isolated from the Moloney murine sarcoma virus (Mo-MSV).

Gag-jun, p65
Transforming protein coded by jun oncogenes (GENES, JUN). This is a gag-onc fusion protein of about 65 kD derived from avian sarcoma virus. v-jun lacks a negative regulatory domain that regulates transcription in c-jun.

Gag-mos Fusion Proteins
Transforming proteins coded by mos oncogenes. The v-mos proteins were originally isolated from the Moloney murine sarcoma virus (Mo-MSV).

Gag-jun Fusion Proteins
Transforming protein coded by jun oncogenes (GENES, JUN). This is a gag-onc fusion protein of about 65 kD derived from avian sarcoma virus. v-jun lacks a negative regulatory domain that regulates transcription in c-jun.

Gag-fps, p140
General name for the translation products of a fusion mRNA consisting of a gag gene and a viral oncogene (v-onc). These products are thought to have the ability to transform cells.

Gag-fos-fox Fusion Proteins

Gag-fes, pp85
General name for the translation products of a fusion mRNA consisting of a gag gene and a viral oncogene (v-onc). These products are thought to have the ability to transform cells.

Gag-fes, p140
General name for the translation products of a fusion mRNA consisting of a gag gene and a viral oncogene (v-onc). These products are thought to have the ability to transform cells.

Gait Ataxias, Cerebellar
Impairment of the ability to coordinate the movements required for normal ambulation which may result from impairments of motor function or sensory feedback. This condition may be associated with BRAIN DISEASES (including CEREBELLAR DISEASES and BASAL GANGLIA DISEASES); SPINAL CORD DISEASES; or PERIPHERAL NERVOUS SYSTEM DISEASES.

Gait Ataxias
Impairment of the ability to coordinate the movements required for normal ambulation which may result from impairments of motor function or sensory feedback. This condition may be associated with BRAIN DISEASES (including CEREBELLAR DISEASES and BASAL GANGLIA DISEASES); SPINAL CORD DISEASES; or PERIPHERAL NERVOUS SYSTEM DISEASES.

Gait Ataxia, Sensory
Impairment of the ability to coordinate the movements required for normal ambulation which may result from impairments of motor function or sensory feedback. This condition may be associated with BRAIN DISEASES (including CEREBELLAR DISEASES and BASAL GANGLIA DISEASES); SPINAL CORD DISEASES; or PERIPHERAL NERVOUS SYSTEM DISEASES.

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