Fructose Metabolism, Inborn Errors
Health dictionary
Untitled Document
Search :      

Art dictionary
Financial dictionary
Hollywood dictionary
Insurance dictionary
Literature dictionary
Real Estate dictionary
Tourism dictionary

 
  Fructose Metabolism, Inborn Errors



Fructose Metabolism, Inborn Errors

   Inherited abnormalities of fructose metabolism, which include three known autosomal recessive types: hepatic fructokinase deficiency (essential fructosuria), hereditary fructose intolerance, and hereditary fructose-1,6-diphosphatase deficiency. Essential fructosuria is a benign asymptomatic metabolic disorder caused by deficiency in fructokinase, leading to decreased conversion of fructose to fructose-1-phosphate and alimentary hyperfructosemia, but with no clinical dysfunction; may produce a false-positive diabetes test.

RELATED TERMS
--------------------------------------

Fructose
Fruit sugar.

Metabolism
The chemical activity that occurs in cells, releasing energy from nutrients, or using energy to create other substances, such as proteins.

Autosomal
"Pertaining to a chromosome that is not a sex chromosome; relating to any one of the chromosomes save the sex chromosomes. People normally have 22 pairs of autosomes (44 autosomes) in each cell together with two sex chromosomes (X and Y in the male and XX in the female). "

Hepatic
Related to the liver.

Hereditary
Transmitted from parent to offspring; derived from ancestry.

Intolerance
Allergy to a food, drug, or other substance.

Fructose-1,6-diphosphatase
An enzyme that catalyzes the conversion of D-fructose 1,6-bisphosphate and water to D-fructose 6-phosphate and orthophosphate. EC 3.1.3.11.

Essential
1. Something that cannot be done without. 2. Required in the diet, because the body cannot make it. As in an essential amino acid or an essential fatty acid. 3. Idiopathic. As in essential hypertension.

Benign
Non-malignant; not life-threatening.

Asymptomatic
The condition of having a disease, but without any symptoms of it.

Conversion
A defense mechanism, operating unconsciously, by which intrapsychic conflicts that would otherwise give rise to anxiety are instead given symbolic external expression. The repressed ideas or impulses, and the psychological defenses against them, are converted into a variety of somatic symptoms. These may include such symptoms as paralysis, pain, or loss of sensory function.

Alimentary
Having to do with food or nutrition. The alimentary tract is the digestive tract.

Clinical
That which can be observed in patients. Research that uses patients to test new treatments, as opposed to laboratory testing or research in animals.

Dysfunction
Difficult function or abnormal function.

Diabetes
A condition in which blood glucose is not well controlled. Type I diabetics make no insulin, whereas type 2 diabetics are characterized by the overproduction of insulin, but the inability of the target cells to respond to the insulin.



SIMILAR TERMS
--------------------------------------

Fructans
Polysaccharides composed of D-fructose units.

Fructokinases
A class of enzymes that catalyzes the phosphorylation of fructose in the presence of ATP. EC 2.7.1.-.

Fructosamine
A term referring to the linking of blood sugar onto protein molecules in the bloodstream. The fructosamine value depends upon the average blood sugar level during the past three weeks. The fructosamine test could be viewed as complementary to the glycohemoglobin, as the two tests are different reflections of diabetes control: glycohemoglobin looks back approximately eight to twelve weeks, and the fructosamine test looks back about three weeks. |Note: the term fructosamine has nothing to do with the term fructose.

Fructose
Fruit sugar.

Fructose 1 Phosphate Aldolase
An enzyme of the lyase class that catalyzes the cleavage of fructose 1,6-biphosphate to form dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. The enzyme also acts on (3S,4R)-ketose 1-phosphates. The yeast and bacterial enzymes are zinc proteins. (Enzyme Nomenclature, 1992) E.C. 4.1.2.13.

Fructose 1,6 Biphosphatase
An enzyme that catalyzes the conversion of D-fructose 1,6-bisphosphate and water to D-fructose 6-phosphate and orthophosphate. EC 3.1.3.11.

Fructose 1,6 Bisphosphatase
An enzyme that catalyzes the conversion of D-fructose 1,6-bisphosphate and water to D-fructose 6-phosphate and orthophosphate. EC 3.1.3.11.

Fructose 1,6 Bisphosphatase Deficiency
An autosomal recessive fructose metabolism disorder due to absent or deficient fructose-1,6-diphosphatase activity. Gluconeogenesis is impaired, resulting in accumulation of gluconeogenic precursors (e.g., amino acids, lactate, ketones) and manifested as hypoglycemia, ketosis, and lactic acidosis. Episodes in the newborn infant are often lethal. Later episodes are often brought on by fasting and febrile infections. As patients age through early childhood, tolerance to fasting improves and development becomes normal.

Fructose 1,6 Bisphosphate Aldolase
An enzyme of the lyase class that catalyzes the cleavage of fructose 1,6-biphosphate to form dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. The enzyme also acts on (3S,4R)-ketose 1-phosphates. The yeast and bacterial enzymes are zinc proteins. (Enzyme Nomenclature, 1992) E.C. 4.1.2.13.

Fructose 1,6 Diphosphatase
An enzyme that catalyzes the conversion of D-fructose 1,6-bisphosphate and water to D-fructose 6-phosphate and orthophosphate. EC 3.1.3.11.

Fructose 1,6 Diphosphatase Deficiency
An autosomal recessive fructose metabolism disorder due to absent or deficient fructose-1,6-diphosphatase activity. Gluconeogenesis is impaired, resulting in accumulation of gluconeogenic precursors (e.g., amino acids, lactate, ketones) and manifested as hypoglycemia, ketosis, and lactic acidosis. Episodes in the newborn infant are often lethal. Later episodes are often brought on by fasting and febrile infections. As patients age through early childhood, tolerance to fasting improves and development becomes normal.

Fructose 1,6-Bisphosphate Aldolase
An enzyme of the lyase class that catalyzes the cleavage of fructose 1,6-biphosphate to form dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. The enzyme also acts on (3S,4R)-ketose 1-phosphates. The yeast and bacterial enzymes are zinc proteins. (Enzyme Nomenclature, 1992) E.C. 4.1.2.13.

Fructose 1,6-Bisphosphate Aldolase, Class II
An enzyme of the lyase class that catalyzes the cleavage of fructose 1,6-biphosphate to form dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. The enzyme also acts on (3S,4R)-ketose 1-phosphates. The yeast and bacterial enzymes are zinc proteins. (Enzyme Nomenclature, 1992) E.C. 4.1.2.13.

Fructose 1-Phosphate Aldolase
An enzyme of the lyase class that catalyzes the cleavage of fructose 1,6-biphosphate to form dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. The enzyme also acts on (3S,4R)-ketose 1-phosphates. The yeast and bacterial enzymes are zinc proteins. (Enzyme Nomenclature, 1992) E.C. 4.1.2.13.

Fructose 2,6-bisphosphatase
An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.

Fructose Biphosphatase Deficiency
An autosomal recessive fructose metabolism disorder due to absent or deficient fructose-1,6-diphosphatase activity. Gluconeogenesis is impaired, resulting in accumulation of gluconeogenic precursors (e.g., amino acids, lactate, ketones) and manifested as hypoglycemia, ketosis, and lactic acidosis. Episodes in the newborn infant are often lethal. Later episodes are often brought on by fasting and febrile infections. As patients age through early childhood, tolerance to fasting improves and development becomes normal.

Fructose Biphosphate Aldolase
An enzyme of the lyase class that catalyzes the cleavage of fructose 1,6-biphosphate to form dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. The enzyme also acts on (3S,4R)-ketose 1-phosphates. The yeast and bacterial enzymes are zinc proteins. (Enzyme Nomenclature, 1992) E.C. 4.1.2.13.

Fructose Bisphosphatase
An enzyme that catalyzes the conversion of D-fructose 1,6-bisphosphate and water to D-fructose 6-phosphate and orthophosphate. EC 3.1.3.11.

Fructose Bisphosphate Aldolase
An enzyme of the lyase class that catalyzes the cleavage of fructose 1,6-biphosphate to form dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. The enzyme also acts on (3S,4R)-ketose 1-phosphates. The yeast and bacterial enzymes are zinc proteins. (Enzyme Nomenclature, 1992) E.C. 4.1.2.13.

Fructose Intolerance
An autosomal recessive fructose metabolism disorder due to deficient fructose-1-phosphate aldolase (EC 2.1.2.13) activity, resulting in accumulation of fructose-1-phosphate. The accumulated fructose-1-phosphate inhibits glycogenolysis and gluconeogenesis, causing severe hypoglycemia following ingestion of fructose. Prolonged fructose ingestion in infants leads ultimately to hepatic failure and death. Patients develop a strong distaste for sweet food, and avoid a chronic course of the disease by remaining on a fructose- and sucrose-free diet.

Fructose Intolerances
An autosomal recessive fructose metabolism disorder due to deficient fructose-1-phosphate aldolase (EC 2.1.2.13) activity, resulting in accumulation of fructose-1-phosphate. The accumulated fructose-1-phosphate inhibits glycogenolysis and gluconeogenesis, causing severe hypoglycemia following ingestion of fructose. Prolonged fructose ingestion in infants leads ultimately to hepatic failure and death. Patients develop a strong distaste for sweet food, and avoid a chronic course of the disease by remaining on a fructose- and sucrose-free diet.

Fructose-1,6-Biphosphatase
An enzyme that catalyzes the conversion of D-fructose 1,6-bisphosphate and water to D-fructose 6-phosphate and orthophosphate. EC 3.1.3.11.

Fructose-1,6-Bisphosphatase
An enzyme that catalyzes the conversion of D-fructose 1,6-bisphosphate and water to D-fructose 6-phosphate and orthophosphate. EC 3.1.3.11.

Fructose-1,6-Bisphosphatase Deficiencies
An autosomal recessive fructose metabolism disorder due to absent or deficient fructose-1,6-diphosphatase activity. Gluconeogenesis is impaired, resulting in accumulation of gluconeogenic precursors (e.g., amino acids, lactate, ketones) and manifested as hypoglycemia, ketosis, and lactic acidosis. Episodes in the newborn infant are often lethal. Later episodes are often brought on by fasting and febrile infections. As patients age through early childhood, tolerance to fasting improves and development becomes normal.

Fructose-1,6-Bisphosphatase Deficiency
An autosomal recessive fructose metabolism disorder due to absent or deficient fructose-1,6-diphosphatase activity. Gluconeogenesis is impaired, resulting in accumulation of gluconeogenic precursors (e.g., amino acids, lactate, ketones) and manifested as hypoglycemia, ketosis, and lactic acidosis. Episodes in the newborn infant are often lethal. Later episodes are often brought on by fasting and febrile infections. As patients age through early childhood, tolerance to fasting improves and development becomes normal.

Fructose-1,6-Diphosphatase
An enzyme that catalyzes the conversion of D-fructose 1,6-bisphosphate and water to D-fructose 6-phosphate and orthophosphate. EC 3.1.3.11.

Fructose-1,6-Diphosphatase Deficiencies
An autosomal recessive fructose metabolism disorder due to absent or deficient fructose-1,6-diphosphatase activity. Gluconeogenesis is impaired, resulting in accumulation of gluconeogenic precursors (e.g., amino acids, lactate, ketones) and manifested as hypoglycemia, ketosis, and lactic acidosis. Episodes in the newborn infant are often lethal. Later episodes are often brought on by fasting and febrile infections. As patients age through early childhood, tolerance to fasting improves and development becomes normal.

Fructose-1,6-Diphosphatase Deficiency
An autosomal recessive fructose metabolism disorder due to absent or deficient fructose-1,6-diphosphatase activity. Gluconeogenesis is impaired, resulting in accumulation of gluconeogenic precursors (e.g., amino acids, lactate, ketones) and manifested as hypoglycemia, ketosis, and lactic acidosis. Episodes in the newborn infant are often lethal. Later episodes are often brought on by fasting and febrile infections. As patients age through early childhood, tolerance to fasting improves and development becomes normal.

Fructose-2,6-bisphosphatase
An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.

Fructose-2,6-bisphosphate 2-phosphatase
An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.

Fructose-2,6-diphosphatase
An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.

Fructose-6-P 1-Kinase
An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-1,6-bisphosphate. D-tagatose- 6-phosphate and sedoheptulose-7-phosphate also are acceptors. UTP, CTP, and ITP also are donors. In human phosphofructokinase-1, three types of subunits have been identified. They are muscle type M (PHOSPHOFRUCTOKINASE-1, MUSCLE TYPE); liver type L (PHOSPHOFRUCTOKINASE-1, LIVER TYPE); and type C (PHOSPHOFRUCTOKINASE-1, C TYPE) found in platelets, brain, and other tissues.

Fructose-6-P,2-kinase
An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.

Fructose-6-phosphate 1-Phosphotransferase
An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-1,6-bisphosphate. D-tagatose- 6-phosphate and sedoheptulose-7-phosphate also are acceptors. UTP, CTP, and ITP also are donors. In human phosphofructokinase-1, three types of subunits have been identified. They are muscle type M (PHOSPHOFRUCTOKINASE-1, MUSCLE TYPE); liver type L (PHOSPHOFRUCTOKINASE-1, LIVER TYPE); and type C (PHOSPHOFRUCTOKINASE-1, C TYPE) found in platelets, brain, and other tissues.

Fructose-6-phosphate,2-kinase
An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.

Fructose-6-phosphate,2-kinase-fructose-2,6-bisphosphatase
An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.

Fructose-Biphosphatase Deficiencies
An autosomal recessive fructose metabolism disorder due to absent or deficient fructose-1,6-diphosphatase activity. Gluconeogenesis is impaired, resulting in accumulation of gluconeogenic precursors (e.g., amino acids, lactate, ketones) and manifested as hypoglycemia, ketosis, and lactic acidosis. Episodes in the newborn infant are often lethal. Later episodes are often brought on by fasting and febrile infections. As patients age through early childhood, tolerance to fasting improves and development becomes normal.

Fructose-Biphosphatase Deficiency
An autosomal recessive fructose metabolism disorder due to absent or deficient fructose-1,6-diphosphatase activity. Gluconeogenesis is impaired, resulting in accumulation of gluconeogenic precursors (e.g., amino acids, lactate, ketones) and manifested as hypoglycemia, ketosis, and lactic acidosis. Episodes in the newborn infant are often lethal. Later episodes are often brought on by fasting and febrile infections. As patients age through early childhood, tolerance to fasting improves and development becomes normal.

Fructose-Bisphosphatase
An enzyme that catalyzes the conversion of D-fructose 1,6-bisphosphate and water to D-fructose 6-phosphate and orthophosphate. EC 3.1.3.11.

Fructose-Bisphosphate Aldolase
An enzyme of the lyase class that catalyzes the cleavage of fructose 1,6-biphosphate to form dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. The enzyme also acts on (3S,4R)-ketose 1-phosphates. The yeast and bacterial enzymes are zinc proteins. (Enzyme Nomenclature, 1992) E.C. 4.1.2.13.

Fructosediphosphatase
An enzyme that catalyzes the conversion of D-fructose 1,6-bisphosphate and water to D-fructose 6-phosphate and orthophosphate. EC 3.1.3.11.

Fructosediphosphatase Deficiencies
An autosomal recessive fructose metabolism disorder due to absent or deficient fructose-1,6-diphosphatase activity. Gluconeogenesis is impaired, resulting in accumulation of gluconeogenic precursors (e.g., amino acids, lactate, ketones) and manifested as hypoglycemia, ketosis, and lactic acidosis. Episodes in the newborn infant are often lethal. Later episodes are often brought on by fasting and febrile infections. As patients age through early childhood, tolerance to fasting improves and development becomes normal.

Fructosediphosphatase Deficiency
An autosomal recessive fructose metabolism disorder due to absent or deficient fructose-1,6-diphosphatase activity. Gluconeogenesis is impaired, resulting in accumulation of gluconeogenic precursors (e.g., amino acids, lactate, ketones) and manifested as hypoglycemia, ketosis, and lactic acidosis. Episodes in the newborn infant are often lethal. Later episodes are often brought on by fasting and febrile infections. As patients age through early childhood, tolerance to fasting improves and development becomes normal.

Fructosediphosphate Aldolase
An enzyme of the lyase class that catalyzes the cleavage of fructose 1,6-biphosphate to form dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. The enzyme also acts on (3S,4R)-ketose 1-phosphates. The yeast and bacterial enzymes are zinc proteins. (Enzyme Nomenclature, 1992) E.C. 4.1.2.13.

Fructosediphosphates
Diphosphoric acid esters of fructose. The fructose-1,6- diphosphate isomer is most prevalent. It is an important intermediate in the glycolysis process.

Fructosemonophosphate Aldolase
An enzyme of the lyase class that catalyzes the cleavage of fructose 1,6-biphosphate to form dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. The enzyme also acts on (3S,4R)-ketose 1-phosphates. The yeast and bacterial enzymes are zinc proteins. (Enzyme Nomenclature, 1992) E.C. 4.1.2.13.

Fructuronate Reductase
An enzyme that catalyzes the reversible oxidation of mannonate to fructuronate in the presence of NAD. Also reduces D-tagaturonate to D-altronate. EC 1.1.1.57.



PREVIOUS AND NEXT TERMS
--------------------------------------

Frostbites
Damage to tissues as the result of low environmental temperatures.

Fructose 1,6 Bisphosphate Aldolase
An enzyme of the lyase class that catalyzes the cleavage of fructose 1,6-biphosphate to form dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. The enzyme also acts on (3S,4R)-ketose 1-phosphates. The yeast and bacterial enzymes are zinc proteins. (Enzyme Nomenclature, 1992) E.C. 4.1.2.13.

Fructokinases
A class of enzymes that catalyzes the phosphorylation of fructose in the presence of ATP. EC 2.7.1.-.

Fructans
Polysaccharides composed of D-fructose units.

Fru-kinase-Fru-bisphosphatase
An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.

Fructose Metabolism, Inborn Errors

Fructose Intolerances
An autosomal recessive fructose metabolism disorder due to deficient fructose-1-phosphate aldolase (EC 2.1.2.13) activity, resulting in accumulation of fructose-1-phosphate. The accumulated fructose-1-phosphate inhibits glycogenolysis and gluconeogenesis, causing severe hypoglycemia following ingestion of fructose. Prolonged fructose ingestion in infants leads ultimately to hepatic failure and death. Patients develop a strong distaste for sweet food, and avoid a chronic course of the disease by remaining on a fructose- and sucrose-free diet.

Fructose-6-P 1-Kinase
An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-1,6-bisphosphate. D-tagatose- 6-phosphate and sedoheptulose-7-phosphate also are acceptors. UTP, CTP, and ITP also are donors. In human phosphofructokinase-1, three types of subunits have been identified. They are muscle type M (PHOSPHOFRUCTOKINASE-1, MUSCLE TYPE); liver type L (PHOSPHOFRUCTOKINASE-1, LIVER TYPE); and type C (PHOSPHOFRUCTOKINASE-1, C TYPE) found in platelets, brain, and other tissues.

Fruits, Citrus
A plant genus of the family RUTACEAE. Species in this genus include orange, grapefruit, lemon, and lime.

Fruits
The fleshy or dry ripened ovary of a plant, enclosing the seed or seeds.

Frugiperdas, Spodoptera
A genus of owlet moths of the family Noctuidae. These insects are used in molecular biology studies during all stages of their life cycle.

   We thank you for using the Health Dictionary to search for Fructose Metabolism, Inborn Errors. If you have a better definition for Fructose Metabolism, Inborn Errors than the one presented here, please let us know by making use of the suggest a term option. This definition of Fructose Metabolism, Inborn Errors may be disputed by other professionals. Our attempt is to provide easy definitions on Fructose Metabolism, Inborn Errors and any other medical topic for the public at large.
 
This dictionary contains 59020 terms.      









  
                    © Health Dictionary 2005 - All rights reserved -

   fructosemetabolism,inbornerrors / ructose metabolism, inborn errors / fuctose metabolism, inborn errors / frctose metabolism, inborn errors / frutose metabolism, inborn errors / frucose metabolism, inborn errors / fructse metabolism, inborn errors / fructoe metabolism, inborn errors / fructos metabolism, inborn errors / fructosemetabolism, inborn errors / fructose etabolism, inborn errors / fructose mtabolism, inborn errors / fructose meabolism, inborn errors / fructose metbolism, inborn errors / fructose metaolism, inborn errors / fructose metablism, inborn errors / fructose metaboism, inborn errors / fructose metabolsm, inborn errors / fructose metabolim, inborn errors / fructose metabolis, inborn errors / fructose metabolism inborn errors / fructose metabolism,inborn errors / fructose metabolism, nborn errors / fructose metabolism, iborn errors / fructose metabolism, inorn errors / fructose metabolism, inbrn errors / fructose metabolism, inbon errors / fructose metabolism, inbor errors / fructose metabolism, inbornerrors / fructose metabolism, inborn rrors / fructose metabolism, inborn erors / fructose metabolism, inborn erors / fructose metabolism, inborn errrs / fructose metabolism, inborn erros / fructose metabolism, inborn error / ffructose metabolism, inborn errors / frructose metabolism, inborn errors / fruuctose metabolism, inborn errors / frucctose metabolism, inborn errors / fructtose metabolism, inborn errors / fructoose metabolism, inborn errors / fructosse metabolism, inborn errors / fructosee metabolism, inborn errors / fructose metabolism, inborn errors / fructose mmetabolism, inborn errors / fructose meetabolism, inborn errors / fructose mettabolism, inborn errors / fructose metaabolism, inborn errors / fructose metabbolism, inborn errors / fructose metaboolism, inborn errors / fructose metabollism, inborn errors / fructose metaboliism, inborn errors / fructose metabolissm, inborn errors / fructose metabolismm, inborn errors / fructose metabolism,, inborn errors / fructose metabolism, inborn errors / fructose metabolism, iinborn errors / fructose metabolism, innborn errors / fructose metabolism, inbborn errors / fructose metabolism, inboorn errors / fructose metabolism, inborrn errors / fructose metabolism, inbornn errors / fructose metabolism, inborn errors / fructose metabolism, inborn eerrors / fructose metabolism, inborn errrors / fructose metabolism, inborn errrors / fructose metabolism, inborn erroors / fructose metabolism, inborn errorrs / fructose metabolism, inborn errorss / rructose metabolism, inborn errors / tructose metabolism, inborn errors / gructose metabolism, inborn errors / bructose metabolism, inborn errors / vructose metabolism, inborn errors / cructose metabolism, inborn errors / dructose metabolism, inborn errors / eructose metabolism, inborn errors / f4uctose metabolism, inborn errors / f5uctose metabolism, inborn errors / ftuctose metabolism, inborn errors / fguctose metabolism, inborn errors / ffuctose metabolism, inborn errors / fductose metabolism, inborn errors / feuctose metabolism, inborn errors / f3uctose metabolism, inborn errors / fr7ctose metabolism, inborn errors / fr8ctose metabolism, inborn errors / frictose metabolism, inborn errors / frkctose metabolism, inborn errors / frjctose metabolism, inborn errors / frhctose metabolism, inborn errors / fryctose metabolism, inborn errors / fr6ctose metabolism, inborn errors / fruxtose metabolism, inborn errors / frustose metabolism, inborn errors / frudtose metabolism, inborn errors / fruftose metabolism, inborn errors / fruvtose metabolism, inborn errors / fru tose metabolism, inborn errors / fruc5ose metabolism, inborn errors / fruc6ose metabolism, inborn errors / frucyose metabolism, inborn errors / fruchose metabolism, inborn errors / frucgose metabolism, inborn errors / frucfose metabolism, inborn errors / frucrose metabolism, inborn errors / fruc4ose metabolism, inborn errors / fruct9se metabolism, inborn errors / fruct0se metabolism, inborn errors / fructpse metabolism, inborn errors / fructlse metabolism, inborn errors / fructkse metabolism, inborn errors / fructise metabolism, inborn errors / fruct8se metabolism, inborn errors / fructowe metabolism, inborn errors / fructoee metabolism, inborn errors / fructode metabolism, inborn errors / fructoxe metabolism, inborn errors / fructoze metabolism, inborn errors / fructoae metabolism, inborn errors / fructoqe metabolism, inborn errors / fructos3 metabolism, inborn errors / fructos4 metabolism, inborn errors / fructosr metabolism, inborn errors / fructosf metabolism, inborn errors / fructosd metabolism, inborn errors / fructoss metabolism, inborn errors / fructosw metabolism, inborn errors / fructose netabolism, inborn errors / fructose jetabolism, inborn errors / fructose ketabolism, inborn errors / fructose ,etabolism, inborn errors / fructose etabolism, inborn errors / fructose m3tabolism, inborn errors / fructose m4tabolism, inborn errors / fructose mrtabolism, inborn errors / fructose mftabolism, inborn errors / fructose mdtabolism, inborn errors / fructose mstabolism, inborn errors / fructose mwtabolism, inborn errors / fructose me5abolism, inborn errors / fructose me6abolism, inborn errors / fructose meyabolism, inborn errors / fructose mehabolism, inborn errors / fructose megabolism, inborn errors / fructose mefabolism, inborn errors / fructose merabolism, inborn errors / fructose me4abolism, inborn errors / fructose metqbolism, inborn errors / fructose metwbolism, inborn errors / fructose metsbolism, inborn errors / fructose metxbolism, inborn errors / fructose metzbolism, inborn errors / fructose metavolism, inborn errors / fructose metafolism, inborn errors / fructose metagolism, inborn errors / fructose metaholism, inborn errors / fructose metanolism, inborn errors / fructose meta olism, inborn errors / fructose metab9lism, inborn errors / fructose metab0lism, inborn errors / fructose metabplism, inborn errors / fructose metabllism, inborn errors / fructose metabklism, inborn errors / fructose metabilism, inborn errors / fructose metab8lism, inborn errors / fructose metabooism, inborn errors / fructose metabopism, inborn errors / fructose metabo;ism, inborn errors / fructose metabo.ism, inborn errors / fructose metabo,ism, inborn errors / fructose metabokism, inborn errors / fructose metaboiism, inborn errors / fructose metabolsm, inborn errors / fructose metaboliwm, inborn errors / fructose metaboliem, inborn errors / fructose metabolidm, inborn errors / fructose metabolixm, inborn errors / fructose metabolizm, inborn errors / fructose metaboliam, inborn errors / fructose metaboliqm, inborn errors / fructose metabolisn, inborn errors / fructose metabolisj, inborn errors / fructose metabolisk, inborn errors / fructose metabolis,, inborn errors / fructose metabolis , inborn errors / fructose metabolism, nborn errors / fructose metabolism, ibborn errors / fructose metabolism, ihborn errors / fructose metabolism, ijborn errors / fructose metabolism, imborn errors / fructose metabolism, i born errors / fructose metabolism, invorn errors / fructose metabolism, inforn errors / fructose metabolism, ingorn errors / fructose metabolism, inhorn errors / fructose metabolism, innorn errors / fructose metabolism, in orn errors / fructose metabolism, inb9rn errors / fructose metabolism, inb0rn errors / fructose metabolism, inbprn errors / fructose metabolism, inblrn errors / fructose metabolism, inbkrn errors / fructose metabolism, inbirn errors / fructose metabolism, inb8rn errors / fructose metabolism, inbo4n errors / fructose metabolism, inbo5n errors / fructose metabolism, inbotn errors / fructose metabolism, inbogn errors / fructose metabolism, inbofn errors / fructose metabolism, inbodn errors / fructose metabolism, inboen errors / fructose metabolism, inbo3n errors / fructose metabolism, inborb errors / fructose metabolism, inborh errors / fructose metabolism, inborj errors / fructose metabolism, inborm errors / fructose metabolism, inbor errors / fructose metabolism, inborn 3rrors / fructose metabolism, inborn 4rrors / fructose metabolism, inborn rrrors / fructose metabolism, inborn frrors / fructose metabolism, inborn drrors / fructose metabolism, inborn srrors / fructose metabolism, inborn wrrors / fructose metabolism, inborn e4rors / fructose metabolism, inborn e5rors / fructose metabolism, inborn etrors / fructose metabolism, inborn egrors / fructose metabolism, inborn efrors / fructose metabolism, inborn edrors / fructose metabolism, inborn eerors / fructose metabolism, inborn e3rors / fructose metabolism, inborn er4ors / fructose metabolism, inborn er5ors / fructose metabolism, inborn ertors / fructose metabolism, inborn ergors / fructose metabolism, inborn erfors / fructose metabolism, inborn erdors / fructose metabolism, inborn ereors / fructose metabolism, inborn er3ors / fructose metabolism, inborn err9rs / fructose metabolism, inborn err0rs / fructose metabolism, inborn errprs / fructose metabolism, inborn errlrs / fructose metabolism, inborn errkrs / fructose metabolism, inborn errirs / fructose metabolism, inborn err8rs / fructose metabolism, inborn erro4s / fructose metabolism, inborn erro5s / fructose metabolism, inborn errots / fructose metabolism, inborn errogs / fructose metabolism, inborn errofs / fructose metabolism, inborn errods / fructose metabolism, inborn erroes / fructose metabolism, inborn erro3s / fructose metabolism, inborn errorw / fructose metabolism, inborn errore / fructose metabolism, inborn errord / fructose metabolism, inborn errorx / fructose metabolism, inborn errorz / fructose metabolism, inborn errora / fructose metabolism, inborn errorq /