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Fluorescence in situ hybridization (FISH)
Fluorescence in situ hybridization (FISH) A technique that can be used for prenatal diagnosis, in which specifically designed fluorescent molecules are used to "light up" particular genes or sections of chromosomes to make them visible under a microscope. The fluorescence makes even small abnormalities in the chromosomes visible.
RELATED TERMS--------------------------------------
Diagnosis
The determination of the presence of a specific disease or infection, usually accomplished by evaluating clinical symptoms and laboratory tests.
Genes
Basic, functional units of heredity, each occupying a specific place on a chromosome.
Chromosomes
Filaments of genetic material in every cell nucleus that are made up of genes and that transmit genetic information from one generation of cells to the next.
Microscope
A microscope (Greek: micron = small and scopos = aim) is an instrument for viewing objects that are too small to be seen by the naked or unaided eye. The science of investigating small objects using such an instrument is called microscopy, and the term microscopic means minute or very small, not easily visible with the unaided eye. In other words, requiring a microscope to examine.
SIMILAR TERMS--------------------------------------
Fluocet
Fluocet is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): fluocinolone acetonide.
Fluocinolone acetonide
Fluocinolone acetonide is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): fluocinolone acetonide.
Fluocinonide
Fluocinonide is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): fluocinonide.
Fluocinonide emulsified base
Fluocinonide emulsified base is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): fluocinonide.
Fluonid
Fluonid is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): fluocinolone acetonide.
Fluor-op
Fluor-op is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): fluorometholone.
Fluorescein
A compound used as a diagnostic aid to show injuries of the cornea or retina of the eye.
Fluorescein angiograms
Photographs of the back of the eye, taken after a fluorescent dye is placed in the blood stream.ÿ This is used to test the circulation in the retina of the eye.
Fluorescein angiography
Fluorescein Angiography is a diagnostic test used to assess pathology that affects the retina, choroid and/or iris of the eye. Fluorescein angiography is used to assess the blood flow of the eye and abnormal states are referred to as either hyperfluorescence or hypofluorescence relative to the normal amount of fluorescence. Fluorescein angiography involves an intravenous injection of sodium Fluorescein ( a dye) into the antecubical vein ( a vein in the arm) and then photographs are taken of the eye as the dye enters and leaves the blood system of the eye. The doctor will evaluate prefilling ( i.e., what the retina and choroid look like before the dye enters the eye), transit ( i.e., first passage of dye through the retina and choroid), recirculation (i.e., fluoroscien has become equally distributed throughout the eye and then starts to circulate through again) and later phase ( i.e., as the fluoroscien is eliminated from the body by the kidneys). The test lasts about 30 minutes. Nausea and vomiting are the most common side effects, occurring in about 5% or less of patients. Severe side effects ( e.g., anaphylaxis, death) have been reported but are very rare.
Fluorescein Angiography
A method of taking a picture of the flow of blood in the vessels of the eye by tracing the progress of an injected dye.
Fluorescent antibody
An antibody coupled with a fluorescent dye, used with a fluorescence microscope to detect antigen on cells, tissues, or microorganisms.
Fluorescent in situ hybridization
An important molecular cytogenetic method for identifying chromosomes and parts of chromosomes, deciphering chromosome rearrangements, and locating genes on chromosomes.
Fluorescent microscope
A microscope equipped to examine material that fluoresces under ultraviolet light. Fluorescence microscopy is based on the principle that fluorescent materials emit visible light when they are irradiated with ultraviolet rays or with violet-blue visible rays.
Fluorescent treponemal antibody absorbed test
A blood serum screening test for syphilis designed to demonstrate the presence or absence of specific antibodies directed against the organism (Treponema pallidum) responsible for syphilis.
Fluoridation
1. In general, treatment with fluoride. 2. Specifically, the addition of fluoride to a water supply to help prevent dental caries.
Fluoride
A compound of fluorine with another element or radical. Fluoride compounds are present in drinking water and some foods. Fluoride ions replace hydroxyl ions in hydroxyapatite in teeth, forming fluorapatite, which leads to fewer cavities. Fluoride compounds are therefore added to some toothpastes and dentists may also give a yearly fluoride treatment. It is generally recommended that fluorides be added to water supplies in which the natural level is less than 0.7 ppm in water to increase the concentration to 0.7-1.2 ppm. The addition of fluoride to water systems is one of the major achievements in public health in the 20th century. Fluoride, in combination with calcium and vitamin D, also increases bone mass and lowers the risk of backbone fractures associated with osteoporosis. The only accepted adverse effect of fluoridation is dental fluorosis.
Fluorine f-18
Fluorine f-18 is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): sodium fluoride, f-18.
Fluorobody
A hybrid molecule that combines the affinity and specificity of an antibody with the visibility of a green fluorescent protein (GFP). The GSP provides the antibody with a built-in detection system.
Fluoroplex
Fluoroplex is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): fluorouracil.
Fluoroscopy
An x-ray procedure that makes it possible to see internal organs in motion. Fluoroscopy uses x-ray to produce real-time video images. After the x-rays pass through the patient, instead of using film, they are captured by a device called an image intensifier and converted into light. The light is then captured by a TV camera and displayed on a video monitor.
Fluorosis
An abnormal condition caused by excessive intake of fluorine, characterized chiefly by mottling of the teeth.
Fluorouracil
A much-used anticancer drug that belongs to the family of drugs called antimetabolites. Full name: 5-fluorouracil. Abbreviation: 5-FU. 5-FU is a pyrimidine antagonist. 5-FU is similar in structure to the pyrimidine base thymine and functions to inhibit DNA synthesis both by blocking the formation of normal pyrimidine nucleotides via both enzyme inhibition and by interfering with DNA synthesis after incorporation into a growing DNA molecule. 5-FU is also able to block the production of RNA and thereby induce cell death. 5-FU affects the processing of messenger RNA (mRNA), ribosomal RNA (rRNA), transfer RNA (tRNA), and small nuclear RNA (snRNA). 5-FU may also inhibit cell growth is through its ability to prevent the synthesis of thymine nucleotides from uracil nucleotides.
Fluothane
Fluothane is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): halothane.
Fluotrex
Fluotrex is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): fluocinolone acetonide.
Fluoxetine
A drug used to treat depression. It belongs to the family of drugs called antidepressants.
Fluoxetine hcl
Fluoxetine hcl is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): fluoxetine hydrochloride.
Fluoxymesterone
Fluoxymesterone is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): fluoxymesterone.
PREVIOUS AND NEXT TERMS--------------------------------------
Food intolerance
An adverse food-induced reaction that does not involve the immune system. Lactose intolerance is an example.
Foodborne illness
An acute gastrointestinal infection caused by food that contains harmful bacteria. Also called food poisoning.
Fulminant hepatic failure (FHF)
Liver failure that occurs suddenly in a previously healthy person. The most common causes are acute hepatitis, acetaminophen overdose, and liver damage from prescription drugs.
Functional disorders
Conditions resulting from poor nerve and muscle function. Also called motility disorders.
Functional incontinence
Difficulty reaching a restroom in time because of physical conditions such as arthritis.
Fluorescence in situ hybridization (FISH)
Failure to thrive
Slow growth and development of a baby, characterized by failure to gain weight, delayed development, unwillingness to interact, and gastrointestinal problems. Failure to thrive is almost always the result of inadequate nutrition, whether because of neglect or illness.
Family and Medical Leave Act
Passed in 1993, the U.S. Family and Medical Leave Act mandates up to 12 weeks of unpaid medical leave for employees of companies with more than 50 employees. Under this act, people can also take leave to care for a sick child, parent, or spouse
Family practitioner
An updated version of the general practitioner who provided one-stop care for all ages and both sexes, the family practitioner has several years ofspecialty training in primary care, including obstetrics.
Fertility specialist
An obstetrician / gynecologist who specializes in treating people with fertility problems.
Fetal distress
When a fetus's life is believed to be in danger, most often because of too little oxygen. Signs of fetal distress -- including slowed heartbeat or absence of fetal movement -- call for immediate delivery of the baby.
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