|
| | |
Five-lipoxygenase activating protein
Five-lipoxygenase activating protein A gene that helps make a leukotriene, a signal that activates the white blood cells involved in inflammation. FLAP stands for 5-lipoxygenase-activating protein. FLAP has been implicated in a number of inflammatory responses, including asthma, arthritis, psoriasis, heart attack and stroke. FLAP was the first gene discovered to be a major risk factor for the common form of heart attack and the second major genetic factor identified in the common form of stroke.
RELATED TERMS--------------------------------------
Gene
1. A unit of DNA that carries information for the biosynthesis of a specific product in the cell. 2. Ultimate unit by which inheritable characteristics are transmitted to succeeding generations in all living organisms. Genes are contained by, and arranged along the length of, the chromosome. The gene is composed of deoxyribonucleic acid (DNA). Each chromosome of each species has a definite number and arrangement of genes, which govern both the structure and metabolic functions of the cells and thus of the entire organism.
Blood
The life-maintaining fluid which is made up of plasma, red blood cells (erythrocytes), white blood cells (leukocytes), and platelets; blood circulates through the body's heart, arteries, veins, and capillaries; it carries away waste matter and carbon dioxide, and brings nourishment, electrolytes, hormones, vitamins, antibodies, heat, and oxygen to the tissues.
Inflammation
A reaction to an injury to the body - by infection, chemicals or physical agents. The symptoms can be - depending on the location of the injury- redness, swelling, heat and pain. The purpose of the inflammation is to dilute and destroy the agent causing the inflammation. To do this, the immune system starts a cascade of actions that causes active cells to gather at the affected location. It is these cells and fluids that cause the redness, swelling, heat and pain.
FLAP
A gene that helps make a leukotriene, a signal that activates the white blood cells involved in inflammation. FLAP stands for 5-lipoxygenase-activating protein. FLAP has been implicated in a number of inflammatory responses, including asthma, arthritis, psoriasis, heart attack and stroke. FLAP was the first gene discovered to be a major risk factor for the common form of heart attack and the second major genetic factor identified in the common form of stroke. Also known, confusingly, as 5-lipoxygenase activating protein, five-lipoxygenase-activating protein, five-lipoxygenase activating protein, arachidonate 5-lipoxygenase-activating protein, arachidonate 5-lipoxygenase activating protein, and ALOX5AP.
Protein
Any of a group of complex organic compounds which contain carbon, hydrogen, oxygen, nitrogen, and usually sulfur, the characteristic element being nitrogen. Proteins, the principal constituents of the protoplasm of all cells, are of high molecular weight and consist essentially of combinations of a-amino acids in peptide linkages. Twenty different amino acids are commonly found in proteins, and each protein has a unique genetically defined amino acid sequence which determines its specific shape and function. Their roles include enzymatic catalysis, transport and storage, coordinated motion, nerve impulse generation and many others.
Asthma
Asthma is a chronic, inflammatory lung disease characterized by recurrent breathing problems. People with asthma have acute episodes or when the air passages in their lungs get narrower, and breathing becomes more difficult. Sometimes episodes of asthma are triggered by allergens, although infection, exercise, cold air and other factors are also important triggers.
Arthritis
Inflammation of a joint, usually accompanied by pain, swelling, and stiffness, and resulting from infection, trauma, degenerative changes, metabolic disturbances, or other causes. Arthritis occurs in various forms, such as the arthritis associated with infections, osteoarthritis, or rheumatoid arthritis. Many forms of vasculitis can also be associated with arthritis.
Psoriasis
A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.
Heart
The hollow, muscular organ responsible for pumping blood through the circulatory system.
Stroke
A stroke, or a Cerebrovascular Accident, occurs when blood vessels that deliver oxygen to the brain, either rupture or become clogged, causing brain/nerve cells to die. Results are usually devastating as nerve/brain cells are not replaced. Usually characterized by a slurring of words, weakness on one side of the body, and a drooping facial expression on one side of the face.
Risk
In clinical trials, the probability of harm or discomfort for subjects, arising from the test product. Acceptable risk differs depending on the condition for which a product is being tested. A product for sore throat, for example, will be expected to have a low incidence of side effects. However, unpleasant side effects may be an acceptable risk when testing a promising treatment for a life-threatening illness.
Genetic
Hereditary. Having to do with the genes.
SIMILAR TERMS--------------------------------------
Five Elements (Five Phases)
Earth, Metal, Water, Wood, and Fire as manifestations ("phases" or "transformations") of chi. The expression "five elements" derives from two Chinese words|wu ("five") and xing ("move" or "walk"). Its implicit meaning is "five processes." According to ancient Chinese cosmology, the Five Elements compose everything. In Chinese medicine, each of the Five Elements symbolizes a group of physiologic functions|"Earth" (soil) represents balance or neutrality; Metal (coal, fossils, and inorganic matter), decay; Water (moisture), a state of maximum rest leading to a change of functional direction; Wood (organic matter), a growth phase; and Fire (gases), maximum activity.
Five-day fever
Also called trench fever, this is a disease borne by body lice that was first recognized in the trenches of World War I, when it is estimated to have affected more than a million people in Russia and on the fronts in Europe. Trench fever was again a major problem in the military in World War II and is seen endemically in Mexico, Africa, E. Europe, and elsewhere. The cause of trench fever is Bartonella quintana (also called Rochalimaea quintana), an unusual rickettsial organism that multiplies in the gut of the body louse. Transmission of the rickettsia to people can occur by rubbing infected louse feces into abraded (scuffed) skin or into the conjunctivae (whites of the eyes). The disease is classically a 5-day fever. The onset of symptoms is sudden with high fever, severe headache, back pain and leg pain and a fleeting rash. Recovery takes a month or more. Relapses are common.
PREVIOUS AND NEXT TERMS--------------------------------------
Fish oil, omega-3
A class of fatty acids found in fish oils, especially from salmon and other cold-water fish, that acts to lower the levels of cholesterol and LDL (low-density lipoproteins) in the blood. (LDL cholesterol is the "bad" cholesterol.) Omega-3 fish oil is therefore thought to be a neutraceutical, a food that provides health benefits. Eating fish has been reported to protect against late age-related macular degeneration, a common eye disease. The maximum benefit appears to be from eating fish once a week.
Fish-odor syndrome
An inborn error of metabolism associated with an offensive body odor, the smell of rotting fish, due to the excessive excretion of trimethylaminuria (TMA) in urine, sweat, and breath. Persons with TMA may experience tachycardia (fast heart rate) and severe hypertension (high blood pressure) after eating cheese (which contains tyramine) and after using nasal sprays containing epinephrine. TMA is caused by a mutation (change) in the gene for an enzyme, flavin-containing monooxygenase-3 (FMO3) encoded by a gene on chromosome #1. The FMO3 enzyme metabolizes tyramine (which is in cheese). The syndrome is associated with various psychosocial reactions, including social isolation, clinical depression and attempted suicide.
Fissure, palpebral
The opening for the eye between the eyelids.
Fistula, anal
An opening in the skin near the anus that leads into a blind pouch or may connect through a tunnel with the rectal canal.
Five-day fever
Also called trench fever, this is a disease borne by body lice that was first recognized in the trenches of World War I, when it is estimated to have affected more than a million people in Russia and on the fronts in Europe. Trench fever was again a major problem in the military in World War II and is seen endemically in Mexico, Africa, E. Europe, and elsewhere. The cause of trench fever is Bartonella quintana (also called Rochalimaea quintana), an unusual rickettsial organism that multiplies in the gut of the body louse. Transmission of the rickettsia to people can occur by rubbing infected louse feces into abraded (scuffed) skin or into the conjunctivae (whites of the eyes). The disease is classically a 5-day fever. The onset of symptoms is sudden with high fever, severe headache, back pain and leg pain and a fleeting rash. Recovery takes a month or more. Relapses are common.
Five-lipoxygenase activating protein
Fixation, external
A procedure that stabilizes and joins the ends of fractured (broken) bones by a splint or cast. External fixation is as opposed to internal fixation in which the ends of the fractured bone are joined by mechanical devices such as metal plates, pins, rods, wires or screws.
Fixation, internal
A surgical procedure that stabilizes and joins the ends of fractured (broken) bones by mechanical devices such as metal plates, pins, rods, wires or screws. Internal fixation is as opposed to external fixation of a fracture by a splint or cast.
Fixative
A medium such as a solution or spray that preserves specimens of tissues or cells. Most biopsies and specimens removed at surgery are fixed in a solution such as formalin (dilute formaldehyde) before further processing takes place. Other common ingredients used in fixatives are alcohol, mercuric chloride, potassium dichromate and sodium sulfate.
Flail chest
When enough ribs are broken (usually from a crush injury) to compromise the rigidity of the chest wall. On inspiration, the chest wall moves inward instead of outward and the opposite on expiration.
FLAP
A gene that helps make a leukotriene, a signal that activates the white blood cells involved in inflammation. FLAP stands for 5-lipoxygenase-activating protein. FLAP has been implicated in a number of inflammatory responses, including asthma, arthritis, psoriasis, heart attack and stroke. FLAP was the first gene discovered to be a major risk factor for the common form of heart attack and the second major genetic factor identified in the common form of stroke. Also known, confusingly, as 5-lipoxygenase activating protein, five-lipoxygenase-activating protein, five-lipoxygenase activating protein, arachidonate 5-lipoxygenase-activating protein, arachidonate 5-lipoxygenase activating protein, and ALOX5AP.
We thank you for using the Health Dictionary to search for Five-lipoxygenase activating protein. If you have a better definition for Five-lipoxygenase activating protein than the one presented here, please let us know by making use of the suggest a term option. This definition of Five-lipoxygenase activating protein may be disputed by other professionals. Our attempt is to provide easy definitions on Five-lipoxygenase activating protein and any other medical topic for the public at large.This dictionary contains 25007 terms. |
|
|
