|
| | |
Factor V Leiden
Factor V Leiden A genetic disorder of blood coagulation (clotting) that carries an increased risk of venous thromboembolism - the formation of clots in veins that may break loose and travel through the bloodstream to the lungs or brain. On the molecular level, factor V Leiden is characterized by a G to A substitution at nucleotide 1691 in the gene for factor V that causes a single amino acid replacement in the factor V protein. On the clotting level, factor V Leiden is inactivated about 10 times slower than normal factor V and persists longer in the circulation, resulting in increased generation of thrombin and a hypercoagulable state (thrombophilia).
RELATED TERMS--------------------------------------
Genetic
Hereditary. Having to do with the genes.
Blood
The life-maintaining fluid which is made up of plasma, red blood cells (erythrocytes), white blood cells (leukocytes), and platelets; blood circulates through the body's heart, arteries, veins, and capillaries; it carries away waste matter and carbon dioxide, and brings nourishment, electrolytes, hormones, vitamins, antibodies, heat, and oxygen to the tissues.
Coagulation
In medicine, the clotting of blood. The process by which the blood clots to form solid masses, or clots.
Risk
In clinical trials, the probability of harm or discomfort for subjects, arising from the test product. Acceptable risk differs depending on the condition for which a product is being tested. A product for sore throat, for example, will be expected to have a low incidence of side effects. However, unpleasant side effects may be an acceptable risk when testing a promising treatment for a life-threatening illness.
Venous
Having to do with a vein.
Thromboembolism
A condition in which a blood clot fragment breaks off from one part of the body and blocks a blood vessel in another part of the body.
Veins
Blood vessels that carry blood from the arms, legs, head and body organs back to the heart.
Lungs
The main respiratory organs in the chest where blood is oxygenated.
Brain
"That part of the central nervous system that is located within the cranium (skull). The brain functions as the primary receiver, organizer and distributor of information for the body. It has two (right and left) halves called ""hemispheres."" "
Molecular
Refers to the basic building blocks of the genetic material, such as DNA, genes and the other chemicals involved with the functioning of genes.
Substitution
A defense mechanism, operating unconsciously, by which an unattainable or unacceptable goal, emotion, or object is replaced by one that is more attainable or acceptable.
Gene
1. A unit of DNA that carries information for the biosynthesis of a specific product in the cell. 2. Ultimate unit by which inheritable characteristics are transmitted to succeeding generations in all living organisms. Genes are contained by, and arranged along the length of, the chromosome. The gene is composed of deoxyribonucleic acid (DNA). Each chromosome of each species has a definite number and arrangement of genes, which govern both the structure and metabolic functions of the cells and thus of the entire organism.
Protein
Any of a group of complex organic compounds which contain carbon, hydrogen, oxygen, nitrogen, and usually sulfur, the characteristic element being nitrogen. Proteins, the principal constituents of the protoplasm of all cells, are of high molecular weight and consist essentially of combinations of a-amino acids in peptide linkages. Twenty different amino acids are commonly found in proteins, and each protein has a unique genetically defined amino acid sequence which determines its specific shape and function. Their roles include enzymatic catalysis, transport and storage, coordinated motion, nerve impulse generation and many others.
Clotting
The sealing of a blood vessel with coagulated blood.
Circulation
The flow of blood through the body. Includes the heart, arteries, veins and capillaries.
SIMILAR TERMS--------------------------------------
Factive
Factive is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): gemifloxacin mesylate.
Factor V
A coagulation factor needed for the normal clotting of blood. Also known as proaccelerin.
Factor VIII
Factor eight, a key factor in the process of blood coagulation (clotting). Lack of normal factor VIII causes hemophilia (hemophilia A). The gene for classic hemophilia was long known to be on the X chromosome. Females carry the gene and transmit it to their hemophiliac sons. Female carriers are normal since they have another X chromosome that contains a normal gene to make factor VIII. Each of their sons has a one-half (50:50) risk of being a hemophiliac. Because the gene for hemophilia was clearly on the X chromosome, it was correctly inferred that the normal gene for Factor VIII was on the X. Factor VIII is also known as antihemophiliac factor or antihemophiliac globulin.
Factor X
A coagulation factor, a substance in blood essential to the normal clotting process. Production of factor X takes place in the liver and requires vitamin K. The gene for factor X is located on chromosome 13 and is in band 13q34.
Factor, colony-stimulating
A laboratory-made agent similar to a normally existing substance in the body that stimulates the production of blood cells. The colony-stimulating factors (CSFs) include granulocyte colony-stimulating factors (G-CSF) and granulocyte-macrophage colony-stimulating factors (GM-CSF). Treatment with colony-stimulating factors can help the blood-forming tissue recover from the effects of chemotherapy and radiation therapy.
Factor, rheumatoid
Rheumatoid factor is an antibody that is measurable in the blood. It is commonly used as a blood test for the diagnosis of rheumatoid arthritis. Rheumatoid factor is present in about 80% of adults (but a much lower proportion of children) with rheumatoid arthritis. It is also present in patients with other connective tissue diseases (such as systemic lupus erythematosus) and in some with infectious diseases (such as infectious hepatitis).
Factrel
Factrel is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): gonadorelin hydrochloride.
PREVIOUS AND NEXT TERMS--------------------------------------
Facelift surgery risks
Although infrequent, the risks and complications of facelift surgery include: bleeding, hematoma, bruising; infection; neurological dysfunction (loss of muscle function or sensation), which is usually temporary; widened or thickened scar; loss of hair (around the incision site), asymmetry (unevenness between two sides); and skin necrosis (loss of skin from tissue death).
Facial canal introitus
In anatomy, an introitus is an entrance, one that goes into a canal or hollow organ. The introitus of the facial canal is the entrance to the facial canal, a passage in the temporal bone of the skull through which the facial nerve (the 7th cranial nerve) travels.
Facial muscle
One of the 43 muscles in the human face. The facial muscles convey basic human emotions such as anger, sadness, fear, surprise, disgust, contempt and happiness by very clear facial signals.
Facioscapulohumeral muscular dystrophy
A form of muscular dystrophy that typically begins before age 20 with slowly progressive weakness of the muscles of the face, shoulders, and feet. The severity of the disease is quite variable. Although most people with facioscapulohumeral muscular dystrophy (FSHD) retain the ability to walk, about 20% require a wheelchair. Life expectancy is not shortened. The diagnosis can be confirmed by a DNA test disclosing the deletion of copies of a repeat motif called D4Z4 on chromosome 4. FSHD is inherited in an autosomal dominant manner. Offspring of an affected individual have a 50% chance of inheriting the mutant chromosome 4. About 10-30% of cases are due to a new mutation. Prenatal testing is available.
Factor V
A coagulation factor needed for the normal clotting of blood. Also known as proaccelerin.
Factor V Leiden
Factor VIII
Factor eight, a key factor in the process of blood coagulation (clotting). Lack of normal factor VIII causes hemophilia (hemophilia A). The gene for classic hemophilia was long known to be on the X chromosome. Females carry the gene and transmit it to their hemophiliac sons. Female carriers are normal since they have another X chromosome that contains a normal gene to make factor VIII. Each of their sons has a one-half (50:50) risk of being a hemophiliac. Because the gene for hemophilia was clearly on the X chromosome, it was correctly inferred that the normal gene for Factor VIII was on the X. Factor VIII is also known as antihemophiliac factor or antihemophiliac globulin.
Factor X
A coagulation factor, a substance in blood essential to the normal clotting process. Production of factor X takes place in the liver and requires vitamin K. The gene for factor X is located on chromosome 13 and is in band 13q34.
Factor, colony-stimulating
A laboratory-made agent similar to a normally existing substance in the body that stimulates the production of blood cells. The colony-stimulating factors (CSFs) include granulocyte colony-stimulating factors (G-CSF) and granulocyte-macrophage colony-stimulating factors (GM-CSF). Treatment with colony-stimulating factors can help the blood-forming tissue recover from the effects of chemotherapy and radiation therapy.
Factor, rheumatoid
Rheumatoid factor is an antibody that is measurable in the blood. It is commonly used as a blood test for the diagnosis of rheumatoid arthritis. Rheumatoid factor is present in about 80% of adults (but a much lower proportion of children) with rheumatoid arthritis. It is also present in patients with other connective tissue diseases (such as systemic lupus erythematosus) and in some with infectious diseases (such as infectious hepatitis).
Facultative
1. In general, not obligatory but rather capable of adapting to different conditions. The opposite of facultative is obligate. 2. In bacteriology, bacteria that can grow under either aerobic or anaerobic circumstances (with or without oxygen).
We thank you for using the Health Dictionary to search for Factor V Leiden. If you have a better definition for Factor V Leiden than the one presented here, please let us know by making use of the suggest a term option. This definition of Factor V Leiden may be disputed by other professionals. Our attempt is to provide easy definitions on Factor V Leiden and any other medical topic for the public at large.This dictionary contains 25007 terms. |
|
|
