Factor, rheumatoid

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Factor, rheumatoid

Factor, rheumatoid

Rheumatoid factor is an antibody that is measurable in the blood. It is commonly used as a blood test for the diagnosis of rheumatoid arthritis. Rheumatoid factor is present in about 80% of adults (but a much lower proportion of children) with rheumatoid arthritis. It is also present in patients with other connective tissue diseases (such as systemic lupus erythematosus) and in some with infectious diseases (such as infectious hepatitis).

RELATED TERMS
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Antibody
An infection-fighting protein molecule in blood or secretory fluids that tags, neutralizes, and helps destroy pathogenic microorganisms (eg, bacteria, viruses) or toxins. Antibodies, known generally as immunoglobulins, are made and secreted by B-lymphocytes in response to stimulation by antigens. Each specific antibody binds only to the specific antigen that stimulated its production.

Blood
The life-maintaining fluid which is made up of plasma, red blood cells (erythrocytes), white blood cells (leukocytes), and platelets; blood circulates through the body's heart, arteries, veins, and capillaries; it carries away waste matter and carbon dioxide, and brings nourishment, electrolytes, hormones, vitamins, antibodies, heat, and oxygen to the tissues.

Diagnosis
The determination of the presence of a specific disease or infection, usually accomplished by evaluating clinical symptoms and laboratory tests.

Arthritis
Inflammation of a joint, usually accompanied by pain, swelling, and stiffness, and resulting from infection, trauma, degenerative changes, metabolic disturbances, or other causes. Arthritis occurs in various forms, such as the arthritis associated with infections, osteoarthritis, or rheumatoid arthritis. Many forms of vasculitis can also be associated with arthritis.

Tissue
Biological tissue is a group of cells that perform a similar function.The study of tissues is known as histology, or, in connection with disease, histopathology.The classical tools for studying the tissues are the wax block, the tissue stain, and the optical microscope, though developments in electron microscopy, immunofluorescence, and frozen sections have all added to the sum of knowledge in the last couple of decades.

Systemic
Disease or symptoms that affect many different parts of the body.

Lupus
Lupus is a chronic disease in which the body's immune system, instead of serving its normal protective function, forms antibodies and cells that attack healthy tissues and organs. Discoid Lupus affects the skin, causing a rash and scars, most commonly on the face and upper parts of the body.

SIMILAR TERMS
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Factive
Factive is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): gemifloxacin mesylate.

Factor V
A coagulation factor needed for the normal clotting of blood. Also known as proaccelerin.

Factor V Leiden
A genetic disorder of blood coagulation (clotting) that carries an increased risk of venous thromboembolism - the formation of clots in veins that may break loose and travel through the bloodstream to the lungs or brain. On the molecular level, factor V Leiden is characterized by a G to A substitution at nucleotide 1691 in the gene for factor V that causes a single amino acid replacement in the factor V protein. On the clotting level, factor V Leiden is inactivated about 10 times slower than normal factor V and persists longer in the circulation, resulting in increased generation of thrombin and a hypercoagulable state (thrombophilia).

Factor VIII
Factor eight, a key factor in the process of blood coagulation (clotting). Lack of normal factor VIII causes hemophilia (hemophilia A). The gene for classic hemophilia was long known to be on the X chromosome. Females carry the gene and transmit it to their hemophiliac sons. Female carriers are normal since they have another X chromosome that contains a normal gene to make factor VIII. Each of their sons has a one-half (50:50) risk of being a hemophiliac. Because the gene for hemophilia was clearly on the X chromosome, it was correctly inferred that the normal gene for Factor VIII was on the X. Factor VIII is also known as antihemophiliac factor or antihemophiliac globulin.

Factor X
A coagulation factor, a substance in blood essential to the normal clotting process. Production of factor X takes place in the liver and requires vitamin K. The gene for factor X is located on chromosome 13 and is in band 13q34.

Factor, colony-stimulating
A laboratory-made agent similar to a normally existing substance in the body that stimulates the production of blood cells. The colony-stimulating factors (CSFs) include granulocyte colony-stimulating factors (G-CSF) and granulocyte-macrophage colony-stimulating factors (GM-CSF). Treatment with colony-stimulating factors can help the blood-forming tissue recover from the effects of chemotherapy and radiation therapy.

Factrel
Factrel is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): gonadorelin hydrochloride.

PREVIOUS AND NEXT TERMS
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Factor V
A coagulation factor needed for the normal clotting of blood. Also known as proaccelerin.

Factor V Leiden
A genetic disorder of blood coagulation (clotting) that carries an increased risk of venous thromboembolism - the formation of clots in veins that may break loose and travel through the bloodstream to the lungs or brain. On the molecular level, factor V Leiden is characterized by a G to A substitution at nucleotide 1691 in the gene for factor V that causes a single amino acid replacement in the factor V protein. On the clotting level, factor V Leiden is inactivated about 10 times slower than normal factor V and persists longer in the circulation, resulting in increased generation of thrombin and a hypercoagulable state (thrombophilia).

Factor VIII
Factor eight, a key factor in the process of blood coagulation (clotting). Lack of normal factor VIII causes hemophilia (hemophilia A). The gene for classic hemophilia was long known to be on the X chromosome. Females carry the gene and transmit it to their hemophiliac sons. Female carriers are normal since they have another X chromosome that contains a normal gene to make factor VIII. Each of their sons has a one-half (50:50) risk of being a hemophiliac. Because the gene for hemophilia was clearly on the X chromosome, it was correctly inferred that the normal gene for Factor VIII was on the X. Factor VIII is also known as antihemophiliac factor or antihemophiliac globulin.

Factor X
A coagulation factor, a substance in blood essential to the normal clotting process. Production of factor X takes place in the liver and requires vitamin K. The gene for factor X is located on chromosome 13 and is in band 13q34.

Factor, colony-stimulating
A laboratory-made agent similar to a normally existing substance in the body that stimulates the production of blood cells. The colony-stimulating factors (CSFs) include granulocyte colony-stimulating factors (G-CSF) and granulocyte-macrophage colony-stimulating factors (GM-CSF). Treatment with colony-stimulating factors can help the blood-forming tissue recover from the effects of chemotherapy and radiation therapy.

Factor, rheumatoid

Facultative
1. In general, not obligatory but rather capable of adapting to different conditions. The opposite of facultative is obligate. 2. In bacteriology, bacteria that can grow under either aerobic or anaerobic circumstances (with or without oxygen).

Facultative heterochromatin
Chromosome material that can be either heterochromatin or euchromatin. The inactive X chromosome is made up of facultative heterochromatin. When a woman transmits that X chromosome to a son, the chromosome reverts to the euchromatic state and to genetic activity.

FAE (fetal alcohol effects)
A softer diagnosis than fetal alcohol syndrome (FAS). The diagnosis of possible FAE is considered when: 1. The person has some signs of FAS; 2. The person does not meet all of the necessary criteria for FAS; and 3. There is a history of alcohol exposure before birth.

Fahrenheit
Thermometer scale in which the freezing point of water is 32°F and the boiling point of water 212°F. The Fahrenheit scale is still obstinately in use in the US. This anachronism requires conversion from Centigrade (°C) to Fahrenheit (°F), and vice versa. One degree °C = (5/9)(°F - 32). One degree °F = (9/5)(°C) + 32.

Failure to thrive (FTT)
Refers to a child whose physical growth is significantly less than that of peers. There is no official consensus on what constitutes failure to thrive (FTT). It usually refers to a child whose growth is below the 3rd or 5th percentiles for their age or whose growth has fallen off precipitously and crossed two major growth percentiles (for example, from above the 75th percentile to below the 25th percentile). Failure to thrive in early infancy sometimes results in death, and in older infancy or childhood is an important marker for underlying disease. Causes of failure to thrive are probably many, including unrecognized food allergies leading to refusal of food and vomiting, undiagnosed metabolic disorders, and disease.

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