Enzyme, lysosomal

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Enzyme, lysosomal

Enzyme, lysosomal

An enzyme in an organelle (a little organ) called the lysosome within the cell. Lysosomal enzymes degrade (break down) macromolecules (large molecules) and other materials (such as bacteria) that have been taken up by the cell during the process of endocytosis. In endocytosis, macromolecules and particles from outside the cell are taken up by the cell via a progressive invagination (inpouching) and eventual pinching off of a region of the cell membrane, forming a membrane-bound vesicle (bubble) within the cytoplasm of the cell. The vesicle then fuses with the lysosome and the lysosomal enzymes carry out their appointed task of destruction (by hydrolysis). Quite amazingly, the lysosomal enzymes do not normally damage the cell itself.

RELATED TERMS
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Enzyme
A cellular protein whose shape allows it to hold together several other molecules in close proximity to each other. In this way, enzymes are able to induce chemical reactions in other substances with little expenditure of energy and without being changed themselves. Basically, an enzyme acts as a catalyst.

Cell
Fundamental structural unit of all life. The cell consists primarily of an outer plasma membrane, which separates it from the environment; the genetic material (DNA), which encodes heritable information for the maintainance of life; and the cytoplasm, a heterogeneous assemblage of ions, molecules, and fluid.

Enzymes
Proteins that act as a catalysts in mediating and speeding a specific chemical reaction.

Endocytosis
The process by which extracellular molecules (including hormones) enter a cell.

Membrane
A flexible layer surrounding a cell, organelle (such as the nucleus), or other bodily structure. The movement of molecules across a membrane is strictly regulated in both directions.

Vesicle
1. A small, sac-like cavity. 2. A blister.

Cytoplasm
The living matter within a cell (excluding the nucleus) that is responsible for the function of the cell (for example, protein synthesis).

SIMILAR TERMS
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Enzyme
A cellular protein whose shape allows it to hold together several other molecules in close proximity to each other. In this way, enzymes are able to induce chemical reactions in other substances with little expenditure of energy and without being changed themselves. Basically, an enzyme acts as a catalyst.

Enzyme (natural catalyst)
Any of numerous proteins and protein-nonprotein compounds that living cells produce and that can initiate, or affect the speed of, specific chemical reactions.

Enzyme defect
A disorder resulting from a deficiency (or functional abnormality) of an enzyme. In 1902 Archibald Garrod first attributed a disease to an enzyme defect: an inborn error of metabolism. Today, newborns are routinely screened for certain enzyme defects such as PKU (phenylketonuria) and galactosemia, an error in the handling (metabolism) of the sugar galactose.

Enzyme linked immunosorbent assay (ELISA)
A blood test used to find Helicobacter pylori bacteria. Also used to diagnose an ulcer.

Enzyme replacement
A strategy designed to replace missing enzyme activity in a patient. This strategy currently involves the administration of a purified protein (the enzyme) by intravenous infusion.

Enzyme, restriction
An enzyme from bacteria that can recognize specific base sequences in DNA and cut the DNA at that site (the restriction site). A restriction enzyme acts as a biochemical scissors. Also called a restriction endonuclease. Bacteria use restriction enzymes to defend against bacterial viruses called bacteriophages (or phage). When a phage infects a bacterium, it inserts its DNA into the bacterium so that it is replicated. The restriction enzyme prevents replication of the phage DNA by cutting it into many pieces. Restriction enzymes were named for their ability to restrict, or limit, the number of strains of bacteriophage that can infect bacteria.

Enzyme-linked immunosorbent assay (ELISA)
An assay in which an enzyme is linked to an antibody and a coloured substrate is used to measure the activity of bound enzyme and, hence, the amount of bound antibody.

Enzymes
Proteins that act as a catalysts in mediating and speeding a specific chemical reaction.

Enzymes, yellow
A group of respiratory enzymes that catalyze reactions in the body permitting cells to respire or breathe. These biochemical reactions are termed oxidation-reduction reactions.

PREVIOUS AND NEXT TERMS
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Environmental tobacco smoke
Abbreviated ETS. Secondhand smoke. See: ETS.

Environmental toxicology
The toxicity and toxicology of environmental pollutants in air, dust, sediment, soil and water, and natural toxins in the environment.

Enzootic
Endemic in animals. An enzootic disease is constantly present in an animal population, but usually only affects a small number of animals at any one time.

Enzyme defect
A disorder resulting from a deficiency (or functional abnormality) of an enzyme. In 1902 Archibald Garrod first attributed a disease to an enzyme defect: an inborn error of metabolism. Today, newborns are routinely screened for certain enzyme defects such as PKU (phenylketonuria) and galactosemia, an error in the handling (metabolism) of the sugar galactose.

Enzyme replacement
A strategy designed to replace missing enzyme activity in a patient. This strategy currently involves the administration of a purified protein (the enzyme) by intravenous infusion.

Enzyme, lysosomal

Enzyme, restriction
An enzyme from bacteria that can recognize specific base sequences in DNA and cut the DNA at that site (the restriction site). A restriction enzyme acts as a biochemical scissors. Also called a restriction endonuclease. Bacteria use restriction enzymes to defend against bacterial viruses called bacteriophages (or phage). When a phage infects a bacterium, it inserts its DNA into the bacterium so that it is replicated. The restriction enzyme prevents replication of the phage DNA by cutting it into many pieces. Restriction enzymes were named for their ability to restrict, or limit, the number of strains of bacteriophage that can infect bacteria.

Enzymes
Proteins that act as a catalysts in mediating and speeding a specific chemical reaction.

Enzymes, yellow
A group of respiratory enzymes that catalyze reactions in the body permitting cells to respire or breathe. These biochemical reactions are termed oxidation-reduction reactions.

EOG
Electro-oculography. A type of electrophysiologic retinal testing.

EOS
The gene for familial eosinophilia. EOS has been mapped to chromosome region 5q31-33 containing the cytokine gene cluster which includes the genes for interleukin-3 (IL-3), interleukin-5 (IL-5), and granulocyte colony-stimulating factor (G-CSF), and all of which are thought play roles in the development, proliferation, and activation of eosinophils.

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This dictionary contains 25007 terms.

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