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EAN (Experimental Autoimmune Neuritis)
EAN (Experimental Autoimmune Neuritis) An experimental animal demyelinating disease model of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)
RELATED TERMS--------------------------------------
Disease
Illness or sickness often characterized by typical patient problems (symptoms) and physical findings (signs). Disruption sequence: The events that occur when a fetus that is developing normally is subjected to a destructive agent such as the rubella (German measles) virus.
Model
Reproduction of structures made by pouring plaster or stone into a mold.
SYNDROME
A grouping of signs and symptoms, based on their frequent co-occurrence, that may suggest a common underlying pathogenesis, course, familial pattern, or treatment selection.
Protocol
An outline of care; a treatment plan.
Peripheral
At or near the surface of the body. Located away from the center structure.
Nerve
Tissue that conveys sensation, temperature, position information to the brain.
Tissue
Biological tissue is a group of cells that perform a similar function.The study of tissues is known as histology, or, in connection with disease, histopathology.The classical tools for studying the tissues are the wax block, the tissue stain, and the optical microscope, though developments in electron microscopy, immunofluorescence, and frozen sections have all added to the sum of knowledge in the last couple of decades.
Protein
Any of a group of complex organic compounds which contain carbon, hydrogen, oxygen, nitrogen, and usually sulfur, the characteristic element being nitrogen. Proteins, the principal constituents of the protoplasm of all cells, are of high molecular weight and consist essentially of combinations of a-amino acids in peptide linkages. Twenty different amino acids are commonly found in proteins, and each protein has a unique genetically defined amino acid sequence which determines its specific shape and function. Their roles include enzymatic catalysis, transport and storage, coordinated motion, nerve impulse generation and many others.
Neuropathy
A disease of the nervous system. The three major forms in people with diabetes are peripheral neuropathy, autonomic neuropathy, and mononeuropathy. The most common form is peripheral neuropathy, which affects mainly the legs and feet.
Autoimmune
Pertaining to autoimmunity, a misdirected immune response that occurs when the immune system goes awry and attacks the body itself. Autoimmunity is present to some extent in everyone and is usually harmless. However, autoimmunity can cause a broad range of human illnesses, known collectively as autoimmune diseases. Autoimmune diseases occur when there is progression from benign autoimmunity to pathogenic autoimmunity. This progression is determined by genetic influences as well as environmental triggers. Autoimmunity is evidenced by the presence of autoantibodies (antibodies directed against the person who produced them) and T cells that are reactive with host antigens.
MYELIN
The lipid substance forming a sheath around the axons of certain nerve fibers.
Perivascular
Surrounding a blood or lymph vessel.
Syndrome
A grouping of signs and symptoms, based on their frequent co-occurrence, that may suggest a common underlying pathogenesis, course, familial pattern, or treatment selection.
Neurology
The branch of medicine that pertains to the nervous system.
SIMILAR TERMS--------------------------------------
EAN (Experimental Allergic Neuritis)
An experimental animal demyelinating disease model of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)
PREVIOUS AND NEXT TERMS--------------------------------------
Ear Cartilages
Cartilages of the auricle (pinna) and the external acoustic meatus.
Ear Cartilage
Cartilages of the auricle (pinna) and the external acoustic meatus.
Ear Cancers
Tumors or cancer of the internal, external, or middle ear.
Ear Cancer
Tumors or cancer of the internal, external, or middle ear.
Ear Acupunctures
Acupuncture therapy by inserting needles in the ear. It is used to control pain and for treating various ailments.
EAN (Experimental Autoimmune Neuritis)
Ear Acupuncture
Acupuncture therapy by inserting needles in the ear. It is used to control pain and for treating various ailments.
Eagle
Members of the Falconiformes order of birds, family Accipitridae. They are characterized by their powerful talons, which carry long, curved, pointed claws and by their opposable hindtoe.
EAN (Experimental Allergic Neuritis)
An experimental animal demyelinating disease model of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)
Eagles
Members of the Falconiformes order of birds, family Accipitridae. They are characterized by their powerful talons, which carry long, curved, pointed claws and by their opposable hindtoe.
EAC142
The enzyme which in both the classical and alternate complement pathways cleaves complement 3 into anaphylatoxin (C3a) and C3b.
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