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Downey Regional Medical Center
Downey Regional Medical Center Downey Regional Medical Center is a hospital in Downey, California (USA).
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Medical
Pertaining to Medicine.
SIMILAR TERMS--------------------------------------
Down East Community Hospital
Down East Community Hospital is a hospital in Machias, Maine (USA).
Down Syndrome
A genetic disorder (caused by the presence of an extra chromosome), which results in physical and mental abnormalities. Physical characteristics include a flattened face, widely spaced and slanted eyes, smaller head size and lax joints. Mental retardation is also typical, though there are wide variations in mental ability, behavior, and developmental progress. Possible related health problems include poor resistance to infection, hearing loss, gastrointestinal problems, and heart defects.
Down syndrome
A genetic disorder characterized by some degree of mental retardation and by various physical malformations, such as slanted eyes and a broad face.
Down syndrome critical region
(Abbreviated DSCR) A region on the long (q) arm of chromosome 21 thought to be responsible for some, if not all, of the features of Down syndrome. A number of genes in this region may be involved in the production of the Down syndrome phenotype. These genes may include the Down syndrome critical region 1 gene or DSCR1 on chromosome 22q11.2; DSCR2 on chromosome 21q22.3; DSCR3 in chromosome 21q22.2; DSCR4 on chromosome 21q22.2; and DSCR5 in chromosome region 21q22.1-q22.2.
Down syndrome features
Children with Down syndrome have multiple malformations and mental impairment due to the presence of extra material from chromosome 21. Among the more common physical features are hypotonia (floppiness), small head with brachycephaly, epicanthic folds across the inside corners of the eyes, upward outward slanting palpebral fissures (eye slits), Brushfield spots in the iris, small mouth, small ears, excessive skin at the nape of the neck, a single transverse palmar crease, and short fifth finger with clinodactyly (incurving). A wide space, often with a deep fissure between the first and second toes, is also common. There is an increased risk of congenital heart defects (50%); leukemia (<1%); hearing loss (75%); otitis media (ear infections) (50%-70%); Hirschsprung disease with absence of nerves from the bowel (<1%); gastrointestinal atresia (12%); eye disease (60%), including cataracts (15%) and severe refractive errors (50%); acquired hip dislocation (6%); obstructive sleep apnea (50%-75%); and thyroid disease (15%). There is no increased risk of solid tumors.
Downregulation
An decrease in the number of receptors on the surface of target cells, making the cells less sensitive to a hormone or another agent. Some receptors can be rapidly down regulated.
Downunder doctor
A doctor who, being or not a citizen of that country, has been admitted to practice medicine in Australia or New Zealand.
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