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Diffuse mastocytosis
Diffuse mastocytosis A form of mastocytosis in which the entire skin is thickened and leathery with generalized reddening and intense pruritus (itching) due to widespread infiltration of the skin with mast cells.
RELATED TERMS--------------------------------------
Skin
Skin is an organ of the integumentary system; which is composed of a layer of tissues that protect underlying muscles and organs. Skin is used for insulation, vitamin D production, sensation, and excretion (through sweat).
Pruritus
Itching. Pruritus can result from drug reaction, food allergy, kidney or liver disease, cancers, parasites, aging or dry skin, contact skin reaction, such as poison ivy, and for unknown reasons.
Infiltration
Local anesthetic procedure effective for upper teeth and soft tissue; placement of anesthetic under the gum, allowing it to seep into bone.
SIMILAR TERMS--------------------------------------
Differential diagnosis
The determination of which two or more diseases with similar symptoms is the one from which a patient is suffering, based on an analysis of the clinical data.
Differential white cell count
The proportions of the different types of white cells in the blood, usually split into the different types of granulocytes, lymphocytes, monocytes, eosinophils, and basophils. The differential white cell count was originally done by visual inspection of the blood and is now often machine-generated. Normal values are: 24-62% neutrophils, 19-53% lymphocytes, 2-12% monocytes, 0-7% eosinophils, and 0-2% basophils.
Differentiate
The process cells undergo as they mature into normal cells. Differentiated cells have distinctive characteristics, perform specific functions, and are less likely to divide. See dedifferentiate, undifferentiated.
Differentiated
Having developed into a specialized cell or tissue type
.
Differentiated cancer
A cancer in which the cells are mature and look like cells in the tissue from it arose. Differentiated cancers tend to be decidedly less aggressive than undifferentiated cancers composed of immature cells.
Differentiation
The process whereby an unspecialized early embryonic cell or stem cell acquires the features of a specialized cell, such as a heart, liver, or muscle cell.
Differentiation antigen
A cell surface antigenic determinant found only on cells of a certain lineage and at a particular developmental stage; used as an immunologic marker.
Differentiation therapy
An approach to the treatment of advanced or aggressive malignancies in which the malignant cells are treated so that they can resume the process of maturation and differentiation into mature cells.
Differin
Differin is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): adapalene.
Diffraction
The scattering of rays of light by collision with particles of matter as they pass through a medium such as air or water, or pass by a edge or narrow aperture. Plays a role when the pupil is small.
Diffuse
Not definitely localized or limited; spread widely through a tissue or substance.
Diffuse degeneration of gray matter with cirrhosis
A progressive disease of the nervous system characterized by spasticity (tightness), myoclonus and dementia and by liver problems with jaundice and cirrhosis.
Diffuse idiopathic skeletal hyperostosis
Abbreviated as DISH. A form of degenerative arthritis characteristically associated with flowing calcification along the sides of the vertebrae of the spine and commonly associated with inflammation (tendinitis) and calcification of the tendons at their attachments points to bone. Because areas of the spine and tendons can become inflamed, antiinflammatory medications (NSAIDs) such ibuprofen can be helpful in both relieving pain and inflammation.
Diffuse toxic goiter
Graves disease, the most common cause of hyperthyroidism (overactivity of the thyroid gland), with generalized diffuse overactivity ("toxicity") of the entire thyroid gland which becomes enlarged into a goiter.
PREVIOUS AND NEXT TERMS--------------------------------------
Differential white cell count
The proportions of the different types of white cells in the blood, usually split into the different types of granulocytes, lymphocytes, monocytes, eosinophils, and basophils. The differential white cell count was originally done by visual inspection of the blood and is now often machine-generated. Normal values are: 24-62% neutrophils, 19-53% lymphocytes, 2-12% monocytes, 0-7% eosinophils, and 0-2% basophils.
Differentiated cancer
A cancer in which the cells are mature and look like cells in the tissue from it arose. Differentiated cancers tend to be decidedly less aggressive than undifferentiated cancers composed of immature cells.
Differentiation therapy
An approach to the treatment of advanced or aggressive malignancies in which the malignant cells are treated so that they can resume the process of maturation and differentiation into mature cells.
Diffuse degeneration of gray matter with cirrhosis
A progressive disease of the nervous system characterized by spasticity (tightness), myoclonus and dementia and by liver problems with jaundice and cirrhosis.
Diffuse idiopathic skeletal hyperostosis
Abbreviated as DISH. A form of degenerative arthritis characteristically associated with flowing calcification along the sides of the vertebrae of the spine and commonly associated with inflammation (tendinitis) and calcification of the tendons at their attachments points to bone. Because areas of the spine and tendons can become inflamed, antiinflammatory medications (NSAIDs) such ibuprofen can be helpful in both relieving pain and inflammation.
Diffuse mastocytosis
Diffuse toxic goiter
Graves disease, the most common cause of hyperthyroidism (overactivity of the thyroid gland), with generalized diffuse overactivity ("toxicity") of the entire thyroid gland which becomes enlarged into a goiter.
DiGeorge syndrome
A genetic disorder characterized by hypocalcemia, immunodeficiency, and congenital heart disease: Hypocalcemia (low calcium levels in the blood) due to hypoplasia (underdevelopment) of the parathyroid glands that are needed to control calcium; Immunodeficiency due to hypoplasia (underdevelopment) of the thymus (an organ behind the breastbone needed for the maturation of lymphocytes into T cells); and Congenital heart disease with defects of the outflow tracts (the pulmonary artery and aorta) from the heart. Next to Down syndrome, DiGeorge syndrome is the most common genetic cause of congenital heart disease.
Digit, supernumerary
An extra finger or toe.
Digital rectal exam
An exam to detect abnormalities that can be felt (palpated) from within the rectum. The doctor inserts a lubricated, gloved finger into the rectum and feels for anything that is not normal.
Dihydroorotate dehydrogenase
An enzyme necessary to pyrimidine synthesis and therefore essential to the production of DNA and RNA. The drug leflunomide (Arava), an immunomodulatory agent, acts by specifically inhibiting dihydroorotate dehydrogenase.
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