Deficiency, glucose-6-phosphate dehydrogenase

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Deficiency, glucose-6-phosphate dehydrogenase

Deficiency, glucose-6-phosphate dehydrogenase

Deficiency of G6PD is the commonest disease-causing enzyme defect in humans affecting an estimated 400 million people. The G6PD gene is on the X chromosome. Males with the enzyme deficiency develop anemia due to breakup of their red blood cells when they are exposed to oxidant drugs such as the antimalarial primaquine, the sulfonamide antibiotics or sulfones, naphthalene moth balls, or fava beans.

RELATED TERMS
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Enzyme
A cellular protein whose shape allows it to hold together several other molecules in close proximity to each other. In this way, enzymes are able to induce chemical reactions in other substances with little expenditure of energy and without being changed themselves. Basically, an enzyme acts as a catalyst.

Gene
1. A unit of DNA that carries information for the biosynthesis of a specific product in the cell. 2. Ultimate unit by which inheritable characteristics are transmitted to succeeding generations in all living organisms. Genes are contained by, and arranged along the length of, the chromosome. The gene is composed of deoxyribonucleic acid (DNA). Each chromosome of each species has a definite number and arrangement of genes, which govern both the structure and metabolic functions of the cells and thus of the entire organism.

Chromosome
A structural unit within a eukaryotic nucleus that carries genes. A chromosome consists of a long, continuous strand of DNA and associated proteins.

Anemia
Anemia is a condition in which a deficiency in the size or number of erythrocytes (red blood cells) or the amount of hemoglobin they contain limits the exchange of oxygen and carbon dioxide between the blood and the tissue cells. Most anemias are caused by a lack of nutrients required for normal erythrocyte synthesis, principally iron, vitamin B-12, and folic acid. Others result from a variety of conditions, such as hemorrhage, genetic abnormalities, chronic disease states or drug toxicity.

Blood
The life-maintaining fluid which is made up of plasma, red blood cells (erythrocytes), white blood cells (leukocytes), and platelets; blood circulates through the body's heart, arteries, veins, and capillaries; it carries away waste matter and carbon dioxide, and brings nourishment, electrolytes, hormones, vitamins, antibodies, heat, and oxygen to the tissues.

Antimalarial
"A drug directed against malaria. The original antimalarial agent was quinine which took its name from the Peruvian Indian word ""kina"" meaning ""bark of the tree."" A large and complex molecule, quinine is the most important alkaloid found in cinchona bark. Until World War I, it was the only effective treatment for malaria. In fact, quinine was the first chemical compound to be successfully used to treat an infectious disease. "

Primaquine
Primaquine is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): primaquine phosphate.

SIMILAR TERMS
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Defiance Regional Medical Center
The Defiance Regional Medical Center is a hospital in Defiance, Ohio, United States.

Defibrillation
The use of a carefully controlled electric shock, administered either through a device on the exterior of the chest wall or directly to the exposed heart muscle, to restart or normalize heart rhythms.

Defibrillator
An electronic device used to establish normal heartbeat.

Defibrillator, implantable cardiac
A device put within the body that is designed to recognize certain types of abnormal heart rhythms (arrhythmias) and correct them.

Deficiency diseases
Any disorder caused by a lack of essential nutrients.

Deficiency, adenosine deaminase (ADA)
A genetic (inherited) condition that results in a immune deficiency disorder called severe combined immunodeficiency disease. Adenosine deaminase is an enzyme that plays a key role in salvaging purine molecules.

Deficiency, ankyrin
Known also as hereditary spherocytosis (HS), this is a genetic disorder of the red blood cell membrane clinically characterized by anemia, jaundice (yellowing) and splenomegaly (enlargement of the spleen), due to deficiency of ankyrin, a protein in the membrane of the red cell.

Deficiency, ceruloplasmin
Lack of the protein ceruloplasmin from the blood and accumulation of iron in the pancreas, liver and brain, causing diabetes and progressive nervous system degeneration with the tremors and gait abnormalities characteristic of Parkinson disease. Ceruloplasmin deficiency is agenetic condition, also known as aceruloplasminemia.

Deficiency, FALDH
Also known as the Sjogren-Larsson syndrome, this is a genetic (inherited) disease usually characterized by a triad of clinical findings consisting of ichthyosis (thickened fish-like skin), spastic paraplegia (spasticity of the legs) and mental retardation.

Deficiency, GALT
Lack of the enzyme called GALT (galactose-1-phosphate uridyl transferase) which causes the genetic metabolic disease galactosemia, one of the diseases in many newborn screening panels. The disease can be fatal, if undetected. If detected, it can be treated by avoiding galactose in the diet.

Deficiency, glucocerebrosidase
Causes type 1 Gaucher disease, a progressive genetic disease due to an enzyme defect. The enzyme, glucocerebrosidase, is needed to break down the chemical glucocerebroside. The enzyme defect leads to the progressive accumulation of glucocerebroside in the spleen, liver, and lymph nodes.

Deficiency, iron
The most common known form of nutritional disorder in the world, iron deficiency results in anemia because iron is necessary to make hemoglobin, key molecule in red blood cells responsible for the transport of oxygen. In iron deficiency anemia, the red cells appear abnormal and are unusually small (microcytic) and pale (hypochromic). The pallor of the red cells reflects their low hemoglobin content.

Deficiency, lactase
Not enough of an enzyme called lactase in the small intestine to digest lactose, a prominent component of milk and most other dairy products. Lactose is sometimes also used as an ingredient in other foods, so anyone with lactase deficiency should check food labels with care.

Deficiency, LCHAD
Acute fatty liver of pregnancy (AFLP) has been found to be associated in some cases with an abnormality of fatty-acid metabolism. This abnormality is a deficiency of the enzyme long-chain-3-hydroxyacyl-CoA dehydrogenease (LCHAD).

Deficiency, magnesium
Can occur due to inadequate intake or impaired intestinal absorption of magnesium. Low magnesium (hypomagnesemia) is often associated with low calcium (hypocalcemia) and potassium (hypokalemia) levels. Deficiency of magnesium causes increased irritability of the nervous system with tetany (spasms of the hands and feet, muscular twitching and cramps, spasm of the larynx, etc.).

Deficiency, protein C
Protein C is a protein in plasma that enters into the cascade of biochemical events leading to the formation of a clot. Deficiency of protein C results in thrombotic (clotting) disease.

Deficiency, selenium
Lack of the essential mineral selenium, which can cause Keshan disease, a fatal form of cardiomyopathy (disease of the heart muscle) that was first observed in Keshan province in China and has since found elsewhere. Treatment involves ensuring adequate selenium. The recommended dietary allowance (RDA) is currently 55 micrograms of selenium per day for adult men and women, 60 micrograms per day for women during pregnancy and 70 micrograms per day for women during lactation. Food sources of selenium include seafoods, some meats such as kidney and liver, and some grains and seeds.

Deficiency, sphingomyelinase
Also called Niemann-Pick disease, this is a disorder of the metabolism of a lipid (fat) called sphingomyelin that usually causes the progressive development of enlargement of the liver and spleen (hepatosplenomegaly), "swollen glands" (lymphadenopathy), anemia and mental and physical deterioration.

Deficiency, UDP-glucuronosyltransferase
Underactivity of a liver enzyme that is essential to the disposal of bilirubin (the chemical that results from the normal breakdown of hemoglobin from red blood cells).

Deficiency, zinc
According to the National Academy of Sciences, the Recommended Dietary Allowances of zinc are 12 milligrams per day for women and 10 milligrams per day for men. Food sources of zinc include meat including liver, eggs, seafood, nuts and cereal.

Definity
Definity is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): perflutren .

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Deficiency, ankyrin
Known also as hereditary spherocytosis (HS), this is a genetic disorder of the red blood cell membrane clinically characterized by anemia, jaundice (yellowing) and splenomegaly (enlargement of the spleen), due to deficiency of ankyrin, a protein in the membrane of the red cell.

Deficiency, ceruloplasmin
Lack of the protein ceruloplasmin from the blood and accumulation of iron in the pancreas, liver and brain, causing diabetes and progressive nervous system degeneration with the tremors and gait abnormalities characteristic of Parkinson disease. Ceruloplasmin deficiency is agenetic condition, also known as aceruloplasminemia.

Deficiency, FALDH
Also known as the Sjogren-Larsson syndrome, this is a genetic (inherited) disease usually characterized by a triad of clinical findings consisting of ichthyosis (thickened fish-like skin), spastic paraplegia (spasticity of the legs) and mental retardation.

Deficiency, GALT
Lack of the enzyme called GALT (galactose-1-phosphate uridyl transferase) which causes the genetic metabolic disease galactosemia, one of the diseases in many newborn screening panels. The disease can be fatal, if undetected. If detected, it can be treated by avoiding galactose in the diet.

Deficiency, glucocerebrosidase
Causes type 1 Gaucher disease, a progressive genetic disease due to an enzyme defect. The enzyme, glucocerebrosidase, is needed to break down the chemical glucocerebroside. The enzyme defect leads to the progressive accumulation of glucocerebroside in the spleen, liver, and lymph nodes.

Deficiency, glucose-6-phosphate dehydrogenase

Deficiency, iron
The most common known form of nutritional disorder in the world, iron deficiency results in anemia because iron is necessary to make hemoglobin, key molecule in red blood cells responsible for the transport of oxygen. In iron deficiency anemia, the red cells appear abnormal and are unusually small (microcytic) and pale (hypochromic). The pallor of the red cells reflects their low hemoglobin content.

Deficiency, lactase
Not enough of an enzyme called lactase in the small intestine to digest lactose, a prominent component of milk and most other dairy products. Lactose is sometimes also used as an ingredient in other foods, so anyone with lactase deficiency should check food labels with care.

Deficiency, LCHAD
Acute fatty liver of pregnancy (AFLP) has been found to be associated in some cases with an abnormality of fatty-acid metabolism. This abnormality is a deficiency of the enzyme long-chain-3-hydroxyacyl-CoA dehydrogenease (LCHAD).

Deficiency, magnesium
Can occur due to inadequate intake or impaired intestinal absorption of magnesium. Low magnesium (hypomagnesemia) is often associated with low calcium (hypocalcemia) and potassium (hypokalemia) levels. Deficiency of magnesium causes increased irritability of the nervous system with tetany (spasms of the hands and feet, muscular twitching and cramps, spasm of the larynx, etc.).

Deficiency, protein C
Protein C is a protein in plasma that enters into the cascade of biochemical events leading to the formation of a clot. Deficiency of protein C results in thrombotic (clotting) disease.

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This dictionary contains 25007 terms.

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dehydrogenase / deficiency, gludose-6-phosphate dehydrogenase / deficiency, glufose-6-phosphate dehydrogenase / deficiency, gluvose-6-phosphate dehydrogenase / deficiency, glu ose-6-phosphate dehydrogenase / deficiency, gluc9se-6-phosphate dehydrogenase / deficiency, gluc0se-6-phosphate dehydrogenase / deficiency, glucpse-6-phosphate dehydrogenase / deficiency, gluclse-6-phosphate dehydrogenase / deficiency, gluckse-6-phosphate dehydrogenase / deficiency, glucise-6-phosphate dehydrogenase / deficiency, gluc8se-6-phosphate dehydrogenase / deficiency, glucowe-6-phosphate dehydrogenase / deficiency, glucoee-6-phosphate dehydrogenase / deficiency, glucode-6-phosphate dehydrogenase / deficiency, glucoxe-6-phosphate dehydrogenase / deficiency, glucoze-6-phosphate dehydrogenase / deficiency, glucoae-6-phosphate dehydrogenase / deficiency, glucoqe-6-phosphate dehydrogenase / deficiency, glucos3-6-phosphate dehydrogenase / deficiency, glucos4-6-phosphate dehydrogenase / deficiency, glucosr-6-phosphate dehydrogenase / deficiency, glucosf-6-phosphate dehydrogenase / deficiency, glucosd-6-phosphate dehydrogenase / deficiency, glucoss-6-phosphate dehydrogenase / deficiency, glucosw-6-phosphate dehydrogenase / deficiency, glucose=6-phosphate dehydrogenase / deficiency, glucose[6-phosphate dehydrogenase / deficiency, glucosep6-phosphate dehydrogenase / deficiency, glucose06-phosphate dehydrogenase / deficiency, glucose-7-phosphate dehydrogenase / deficiency, glucose-u-phosphate dehydrogenase / deficiency, glucose-y-phosphate dehydrogenase / deficiency, glucose-t-phosphate dehydrogenase / deficiency, glucose-5-phosphate dehydrogenase / deficiency, glucose-6=phosphate dehydrogenase / deficiency, glucose-6[phosphate dehydrogenase / deficiency, glucose-6pphosphate dehydrogenase / deficiency, glucose-60phosphate dehydrogenase / deficiency, glucose-6-0hosphate dehydrogenase / deficiency, glucose-6--hosphate dehydrogenase / deficiency, glucose-6-[hosphate dehydrogenase / deficiency, glucose-6-;hosphate dehydrogenase / deficiency, glucose-6-lhosphate dehydrogenase / deficiency, glucose-6-ohosphate dehydrogenase / deficiency, glucose-6-9hosphate dehydrogenase / deficiency, glucose-6-pyosphate dehydrogenase / deficiency, glucose-6-puosphate dehydrogenase / deficiency, glucose-6-pjosphate dehydrogenase / deficiency, glucose-6-pnosphate dehydrogenase / deficiency, glucose-6-pbosphate dehydrogenase / deficiency, glucose-6-pgosphate dehydrogenase / deficiency, glucose-6-ptosphate dehydrogenase / deficiency, glucose-6-ph9sphate dehydrogenase / deficiency, glucose-6-ph0sphate dehydrogenase / deficiency, glucose-6-phpsphate dehydrogenase / deficiency, glucose-6-phlsphate dehydrogenase / deficiency, glucose-6-phksphate dehydrogenase / deficiency, glucose-6-phisphate dehydrogenase / deficiency, glucose-6-ph8sphate dehydrogenase / deficiency, glucose-6-phowphate dehydrogenase / deficiency, glucose-6-phoephate dehydrogenase / deficiency, glucose-6-phodphate dehydrogenase / deficiency, glucose-6-phoxphate dehydrogenase / deficiency, glucose-6-phozphate dehydrogenase / deficiency, glucose-6-phoaphate dehydrogenase / deficiency, glucose-6-phoqphate dehydrogenase / deficiency, glucose-6-phos0hate dehydrogenase / deficiency, glucose-6-phos-hate dehydrogenase / deficiency, glucose-6-phos[hate dehydrogenase / deficiency, glucose-6-phos;hate dehydrogenase / deficiency, glucose-6-phoslhate dehydrogenase / deficiency, glucose-6-phosohate dehydrogenase / deficiency, glucose-6-phos9hate dehydrogenase / deficiency, glucose-6-phospyate dehydrogenase / deficiency, glucose-6-phospuate dehydrogenase / deficiency, glucose-6-phospjate dehydrogenase / deficiency, glucose-6-phospnate dehydrogenase / deficiency, glucose-6-phospbate dehydrogenase / deficiency, glucose-6-phospgate dehydrogenase / deficiency, glucose-6-phosptate dehydrogenase / deficiency, glucose-6-phosphqte dehydrogenase / deficiency, glucose-6-phosphwte dehydrogenase / deficiency, glucose-6-phosphste dehydrogenase / deficiency, glucose-6-phosphxte dehydrogenase / deficiency, glucose-6-phosphzte dehydrogenase / deficiency, glucose-6-phospha5e dehydrogenase / deficiency, glucose-6-phospha6e dehydrogenase / deficiency, glucose-6-phosphaye dehydrogenase / deficiency, glucose-6-phosphahe dehydrogenase / deficiency, glucose-6-phosphage dehydrogenase / deficiency, glucose-6-phosphafe dehydrogenase / deficiency, glucose-6-phosphare dehydrogenase / deficiency, glucose-6-phospha4e dehydrogenase / deficiency, glucose-6-phosphat3 dehydrogenase / deficiency, glucose-6-phosphat4 dehydrogenase / deficiency, glucose-6-phosphatr dehydrogenase / deficiency, glucose-6-phosphatf dehydrogenase / deficiency, glucose-6-phosphatd dehydrogenase / deficiency, glucose-6-phosphats dehydrogenase / deficiency, glucose-6-phosphatw dehydrogenase / deficiency, glucose-6-phosphate eehydrogenase / deficiency, glucose-6-phosphate rehydrogenase / deficiency, glucose-6-phosphate fehydrogenase / deficiency, glucose-6-phosphate vehydrogenase / deficiency, glucose-6-phosphate cehydrogenase / deficiency, glucose-6-phosphate xehydrogenase / deficiency, glucose-6-phosphate sehydrogenase / deficiency, glucose-6-phosphate wehydrogenase / deficiency, glucose-6-phosphate d3hydrogenase / deficiency, glucose-6-phosphate d4hydrogenase / deficiency, glucose-6-phosphate drhydrogenase / deficiency, glucose-6-phosphate dfhydrogenase / deficiency, glucose-6-phosphate ddhydrogenase / deficiency, glucose-6-phosphate dshydrogenase / deficiency, glucose-6-phosphate dwhydrogenase / deficiency, glucose-6-phosphate deyydrogenase / deficiency, glucose-6-phosphate deuydrogenase / deficiency, glucose-6-phosphate dejydrogenase / deficiency, glucose-6-phosphate denydrogenase / deficiency, glucose-6-phosphate debydrogenase / deficiency, glucose-6-phosphate degydrogenase / deficiency, glucose-6-phosphate detydrogenase / deficiency, glucose-6-phosphate deh6drogenase / deficiency, glucose-6-phosphate deh7drogenase / deficiency, glucose-6-phosphate dehudrogenase / deficiency, glucose-6-phosphate dehjdrogenase / deficiency, glucose-6-phosphate dehhdrogenase / deficiency, glucose-6-phosphate dehgdrogenase / deficiency, glucose-6-phosphate dehtdrogenase / deficiency, glucose-6-phosphate deh5drogenase / deficiency, glucose-6-phosphate dehyerogenase / deficiency, glucose-6-phosphate dehyrrogenase / deficiency, glucose-6-phosphate dehyfrogenase / deficiency, glucose-6-phosphate dehyvrogenase / deficiency, glucose-6-phosphate dehycrogenase / deficiency, glucose-6-phosphate dehyxrogenase / deficiency, glucose-6-phosphate dehysrogenase / deficiency, glucose-6-phosphate dehywrogenase / deficiency, glucose-6-phosphate dehyd4ogenase / deficiency, glucose-6-phosphate dehyd5ogenase / deficiency, glucose-6-phosphate dehydtogenase / deficiency, glucose-6-phosphate dehydgogenase / deficiency, glucose-6-phosphate dehydfogenase / deficiency, glucose-6-phosphate dehyddogenase / deficiency, glucose-6-phosphate dehydeogenase / deficiency, glucose-6-phosphate dehyd3ogenase / deficiency, glucose-6-phosphate dehydr9genase / deficiency, glucose-6-phosphate dehydr0genase / deficiency, glucose-6-phosphate dehydrpgenase / deficiency, glucose-6-phosphate dehydrlgenase / deficiency, glucose-6-phosphate dehydrkgenase / deficiency, glucose-6-phosphate dehydrigenase / deficiency, glucose-6-phosphate dehydr8genase / deficiency, glucose-6-phosphate dehydrotenase / deficiency, glucose-6-phosphate dehydrog3nase / deficiency, glucose-6-phosphate dehydrog4nase / deficiency, glucose-6-phosphate dehydrogrnase / deficiency, glucose-6-phosphate dehydrogfnase / deficiency, glucose-6-phosphate dehydrogdnase / deficiency, glucose-6-phosphate dehydrogsnase / deficiency, glucose-6-phosphate dehydrogwnase / deficiency, glucose-6-phosphate dehydrogebase / deficiency, glucose-6-phosphate dehydrogehase / deficiency, glucose-6-phosphate dehydrogejase / deficiency, glucose-6-phosphate dehydrogemase / deficiency, glucose-6-phosphate dehydroge ase / deficiency, glucose-6-phosphate dehydrogenqse / deficiency, glucose-6-phosphate dehydrogenwse / deficiency, glucose-6-phosphate dehydrogensse / deficiency, glucose-6-phosphate dehydrogenxse / deficiency, glucose-6-phosphate dehydrogenzse / deficiency, glucose-6-phosphate dehydrogenawe / deficiency, glucose-6-phosphate dehydrogenaee / deficiency, glucose-6-phosphate dehydrogenade / deficiency, glucose-6-phosphate dehydrogenaxe / deficiency, glucose-6-phosphate dehydrogenaze / deficiency, glucose-6-phosphate dehydrogenaae / deficiency, glucose-6-phosphate dehydrogenaqe / deficiency, glucose-6-phosphate dehydrogenas3 / deficiency, glucose-6-phosphate dehydrogenas4 / deficiency, glucose-6-phosphate dehydrogenasr / deficiency, glucose-6-phosphate dehydrogenasf / deficiency, glucose-6-phosphate dehydrogenasd / deficiency, glucose-6-phosphate dehydrogenass / deficiency, glucose-6-phosphate dehydrogenasw /