Dactinomycin
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  Dactinomycin



Dactinomycin

   An antitumor antibiotic derived from Streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)

RELATED TERMS
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Antibiotic
A drug that stops or slows the growth of bacteria

Termination
The act of ending or concluding. In psychotherapy, termination refers to the mutual agreement between patient and therapist to bring therapy to an end. The idea of termination often occurs to both, but usually it is the therapist who introduces the subject into the session as a possibility to be considered. In psychoanalytic treatment, the patient's reactions are worked through to completion before the treatment ends. The early termination that is characteristic of focal psychotherapy and other forms of brief psychotherapy often requires more extensive work with the feelings of loss and separation.

Protein
Any of a group of complex organic compounds which contain carbon, hydrogen, oxygen, nitrogen, and usually sulfur, the characteristic element being nitrogen. Proteins, the principal constituents of the protoplasm of all cells, are of high molecular weight and consist essentially of combinations of a-amino acids in peptide linkages. Twenty different amino acids are commonly found in proteins, and each protein has a unique genetically defined amino acid sequence which determines its specific shape and function. Their roles include enzymatic catalysis, transport and storage, coordinated motion, nerve impulse generation and many others.

Dactinomycin
An antitumor antibiotic derived from Streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)

Evaluations
Studies determining the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. For drugs and devices, CLINICAL TRIALS; DRUG EVALUATION; and DRUG EVALUATION, PRECLINICAL are available.



SIMILAR TERMS
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Dactarin
An imidazole antifungal agent that is used topically and by intravenous infusion.

Dactyl, dactyl
Prefix or suffix denoting involvement of the digits (fingers or toes).

Dactyledema
Swelling of the fingers or toes.

Dactylitis
Inflammation of a whole digit. Due to tenosynovitis and often periostitis as well as arthritis. Seen in seronegative arthritis (typically psoriatic arthritis) and sarcoidosis.

Dactylolysis Spontanea
Spontaneous autoamputation of the fourth or fifth toe.



PREVIOUS AND NEXT TERMS
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Daflon
A bioflavonoid that strengthens vascular walls.

DADPS
A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)

DADLE
A delta-selective opioid (ANALGESICS, OPIOID). It can cause transient depression of mean arterial blood pressure and heart rate.

DADDS
Acetylated sulfone that is slowly metabolized to give long-term, low blood levels of DAPSONE. It has antimicrobial and antimalarial action, but is mainly used as a depot leprostatic agent.

Dactylolysis Spontanea
Spontaneous autoamputation of the fourth or fifth toe.

Dactinomycin

Dactarin
An imidazole antifungal agent that is used topically and by intravenous infusion.

DAI (Diffuse Axonal Injury)
A relatively common sequela of blunt head injury, characterized by a global disruption of axons throughout the brain. Associated clinical features may include NEUROBEHAVIORAL MANIFESTATIONS; PERSISTENT VEGETATIVE STATE; DEMENTIA; and other disorders.

Daily Allowance, Recommended
Governmental guidelines and objectives pertaining to public food supply and nutrition including recommendations for healthy diet and changes in food habits to ensure healthy diet.

DAHP Synthase
An enzyme that catalyzes the formation of 7-phospho-2-keto-3-deoxy-D-arabinoheptonate from phosphoenolpyruvate and D-erythrose-4-phosphate. It is one of the first enzymes in the biosynthesis of tyrosine and phenylalanine. EC 4.1.12.15.

Dahl Salt-Sensitive Rats
Inbred rats derived from Sprague-Dawley rats and used for the study of salt-dependent hypertension. Salt-sensitive and salt-resistant strains have been selectively bred to show the opposite genetically determined blood pressure responses to excess sodium chloride ingestion.

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