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Coordinating centre
Coordinating centre
Headquarters for a multisite trial that collects all data.
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Coordinating committee
A committee that a sponsor may organise to coordinate the conduct of a multicentre trial.
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Compliance (in relation to trial conduct)
Adherence to all the trial-related requirements, good clinical practice (GCP) requirements, and the applicable regulatory requirements.
Content validity
The extent to which a variable (for example, a rating scale) measures what it is supposed to measure (for example, self-care ability).
Contract
A written, dated, and signed agreement between two or more involved parties that sets out any arrangements on delegation and distribution of tasks and obligations and, if appropriate, on financial matters. The protocol may serve as the basis of a contract.
Control group
The group of subjects in a controlled study that receives no treatment, a standard treatment, or a placebo instead of the therapy being investigated.
Controlled study
A study in which a test treatment is compared with a treatment that has known effects. The control group may receive no treatment, standard treatment, or placebo.
Coordinating centre
Coordinating committee
A committee that a sponsor may organise to coordinate the conduct of a multicentre trial.
Correlation
The relationship of one variable to another, not to be confused with causation.
Crossover trial
In crossover trials, each subject receives both treatments being compared (often the test drug for one period and the placebo for another period). Such trials are used for patients who have a stable, usually chronic, condition during both treatment period.
Cerebrospinal
Relating to the brain and the spinal cord.
Chemoprophylaxis
Prevention of disease by the use of chemicals or drugs.
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