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Constant region
Constant region The invariant carboxyl-terminal portion of an antibody molecule, as distinct from the variable region which is at the amino-terminal of the chain.
RELATED TERMS--------------------------------------
Antibody
An infection-fighting protein molecule in blood or secretory fluids that tags, neutralizes, and helps destroy pathogenic microorganisms (eg, bacteria, viruses) or toxins. Antibodies, known generally as immunoglobulins, are made and secreted by B-lymphocytes in response to stimulation by antigens. Each specific antibody binds only to the specific antigen that stimulated its production.
SIMILAR TERMS--------------------------------------
Consanguinity
Having a common ancestor, ie, being blood relatives. Mating between two first cousins, for example, can be termed a consanguineous mating and is indicated in a pedigree by a double bar between the two parents. Such mating can result in an increased frequency of offspring who are *homozygous* for a recessive autosomal trait possessed by both parents, eg cystic fibrosis.
Conscious
Mentally awake and aware. Knowing what one is doing and why.
Conservative mutation
A change in a DNA or RNA sequence that leads to the replacement of one amino acid with a biochemically similar one. It is conservative in the sense that it is not a radical change that might, for example, stop all protein production.
Conservator
An individual appointed by the court as guardian when a parent can't take care of his or her own child.
Conserved sequence
A base sequence in a DNA molecule (or an amino acid sequence in a protein) that has remained essentially unchanged, and so has been conserved, throughout evolution.
Consolidation therapy
Cancer treatment given after induction therapy to consolidate the gains obtained, further reduce the number of cancer cells and achieve a complete remission. Often just called consolidation. The overall sequence of therapy may be induction, consolidation, and maintenance therapy. Induction therapy is the initial step toward reducing the number of cancer cells. Consolidation is designed to further diminish the number of cancer cells and achieve a complete remission. Maintenance is given to maintain the remission and prevent a relapse.
Consorci Sanitari de Mataro
Consorci Sanitari de Mataro is a hospital in Mataro, Catalonia (Spain).
Constanta doctors
All doctors near Constanta, Romania. Doctors who can assist a patient in Constanta.
Constantiaberg
The Constantiaberg is a hospital in Cape Town, South Africa.
Constantine doctors
All doctors near Constantine, Algeria. Doctors who can assist a patient in Constantine.
Constilac
Constilac is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): lactulose.
Constipation
Infrequent or difficult evacuation of feces.
Constraint-induced movement therapy
A form of intensive physical therapy aimed at reorganizing and reprogramming the brain after a stroke, a traumatic brain injury, or spinal cord damage.
Constricted affect
Affect type that represents mild reduction in the range and intensity of emotional expression.
Constrictive Pericarditis
The pericardium is the sac around the heart. In some patients, this sac can become inflamed and scarred. If this scarring process produces a contracture or shrinkage of the pericardium, it can prevent the heart from filling to its full extent. This disease is known as constrictive pericarditis.
Constructional apraxia
An acquired difficulty in drawing two-dimensional objects or forms, or in producing or copying three-dimensional arrangements of forms or shapes.
Constulose
Constulose is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): lactulose.
Consultant
An individual to whom one refers for expert advice or services. The use of consultants is common in medicine.
Consumption
"1. Using up. 2. Wasting of the body; especially used in reference to advanced tuberculosis."
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Cluster determinant (CD)
Cluster of antigens with which antibodies react that characterize a cell surface marker.
Combinatorial joining
The joining of segments of DNA to generate essentially new genetic information, as occurs with Ig genes during the development of B cells. Combinatorial joining allows multiple opportunities for 2 sets of genes to combine in different ways.
Complement
A series of serum proteins involved in the mediation of immune reactions. The complement cascade is triggered classically by the interaction of antibody with specific antigen.
Complement components
An enzymatic system of serum proteins triggered by the classical and alternative pathways, and resulting in target cell lysis, phagocytosis, opsonization and chemotaxis.
Complement receptor
A structure found on erythrocytes, lymphocytes, neutrophils, monocytes and macrophages that binds C3 fragments.
Constant region
C region
The invariant carboxyl-terminal portion of an antibody molecule, as distinct from the variable region which is at the amino-terminal of the chain.
Coomb's test
A test named for its originator, R.R.A. Coombs, used to detect non-agglutinating antibodies on red blood cells by addition of an anti-immunoglobulin antibody.
Cross-reactivity
The ability of an antibody, specific for one antigen, to react with a second antigen; a measure of relatedness between two different antigenic substances.
Cytotoxic T cell
Cell that kills target cells bearing appropriate antigen within the groove of an MHC class I molecule that is identical to that of the T cell.
Cytolytic T cell
Cell that kills target cells bearing appropriate antigen within the groove of an MHC class I molecule that is identical to that of the T cell.
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