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Connexin
Connexin A subunit of connexon, a protein that forms a gap junction, a channel that permits ions and small molecules to move between adjacent cells. The connexins are important to intercellular communication.
RELATED TERMS--------------------------------------
Connexon
"A special type of protein composed of an assembly of six subunits that are called connexins. A connexon of one cell is joined to that of an adjacent cell to form an intercellular channel consisting of 12 connexin subunits. Clusters of intercellular channels are known as a gap junction because of the minute extracellular ""gap"" that separates the apposed plasma membranes. Each intercellular channel provides an axial channel that interconnects the cytoplasm of the apposed cell directly and permits the passage of ion and other small molecules between adjacent cells."
Protein
Any of a group of complex organic compounds which contain carbon, hydrogen, oxygen, nitrogen, and usually sulfur, the characteristic element being nitrogen. Proteins, the principal constituents of the protoplasm of all cells, are of high molecular weight and consist essentially of combinations of a-amino acids in peptide linkages. Twenty different amino acids are commonly found in proteins, and each protein has a unique genetically defined amino acid sequence which determines its specific shape and function. Their roles include enzymatic catalysis, transport and storage, coordinated motion, nerve impulse generation and many others.
Adjacent
Lying nearby. Related terms include superjacent, subjacent, and circumjacent. From ad-, near + the Latin jacere, to lie = to lie near.
Intercellular
Between two cells.
SIMILAR TERMS--------------------------------------
Conn syndrome
Overproduction of the hormone aldosterone (pronounced al-do-ster-one) by a tumor that contains tissue resembling that normally present in the outer portion (cortex) of the adrenal gland. The excess aldosterone results in a potassium level (hypokalemia), underacidity of the body (alkalosis), muscle weakness, excessive thirst (polydipsia), excessive urination (polyuria), and high blood pressure (hypertension).
Connecticut Children's Medical Center
Connecticut Children's Medical Center is a hospital in Hartford, Connecticut (USA).
Connectionism
A theory of information processing within cognitive science (the study of the mind). Connectionism is based upon the known neurophysiology of the brain.
Connective tissue
Fibrous tissue with a wide variety of connecting and supporting functions within and between body organs.
Connective tissue disease
Connective tissue diseases are inflammatory multisystem diseases characterised by evidence of autoimmunity (e.g. antibodies to cellular components) in which there are often prominent signs of involvement of the joints and other parts of the locomotor system. e.g. SLE.
Connective Tissue Disease
Disease caused by problem with collagen (the elastic support system in the body); can have a vascular component. Examples include Systemic Lupus Erythematosus (SLE), rheumatoid arthritis (RA). Can also be referred to mixed connective tissue diseases (MCTD)
Conner Williams Nursing Home
The Conner Williams Nursing Home is a hospital in Ridley Park, Pennsylvania, United States.
Connexon
"A special type of protein composed of an assembly of six subunits that are called connexins. A connexon of one cell is joined to that of an adjacent cell to form an intercellular channel consisting of 12 connexin subunits. Clusters of intercellular channels are known as a gap junction because of the minute extracellular ""gap"" that separates the apposed plasma membranes. Each intercellular channel provides an axial channel that interconnects the cytoplasm of the apposed cell directly and permits the passage of ion and other small molecules between adjacent cells."
PREVIOUS AND NEXT TERMS--------------------------------------
Conjunctival
Pertaining to the conjunctiva, the clear moist membrane that covers the inner surfaces of the eyelids and the front of eyeball.
Conjunctival fornix
The fornix of the conjunctivae refers to loose arching folds connecting the conjunctival membrane lining the inside of the eyelid with the conjunctival membrane covering the eyeball.
Conjunctivitis, allergic
Inflammation of the whites of the eyes (the conjunctivae) with itching and redness of the eyes and tearing, due to allergy. Frequently accompanies hay fever.
Conn syndrome
Overproduction of the hormone aldosterone (pronounced al-do-ster-one) by a tumor that contains tissue resembling that normally present in the outer portion (cortex) of the adrenal gland. The excess aldosterone results in a potassium level (hypokalemia), underacidity of the body (alkalosis), muscle weakness, excessive thirst (polydipsia), excessive urination (polyuria), and high blood pressure (hypertension).
Connectionism
A theory of information processing within cognitive science (the study of the mind). Connectionism is based upon the known neurophysiology of the brain.
Connexin
Connexon
"A special type of protein composed of an assembly of six subunits that are called connexins. A connexon of one cell is joined to that of an adjacent cell to form an intercellular channel consisting of 12 connexin subunits. Clusters of intercellular channels are known as a gap junction because of the minute extracellular ""gap"" that separates the apposed plasma membranes. Each intercellular channel provides an axial channel that interconnects the cytoplasm of the apposed cell directly and permits the passage of ion and other small molecules between adjacent cells."
Conotoxin
A toxin made by cone snails (Conidae), also called cone shells, which are fish-eating snails that inhabit tropical coral reefs, mangroves and associated habitats. Each of the 500 species of cone snail produces roughly 50 to 100 distinct conotoxins which they use to immobilize prey. These toxins are selective in their receptor binding sites. Conotoxins have been used to characterize receptors in heart muscle, skeletal muscle and brain. Calcium, potassium, and sodium ion channels have also been characterized using conotoxins.
Conservative mutation
A change in a DNA or RNA sequence that leads to the replacement of one amino acid with a biochemically similar one. It is conservative in the sense that it is not a radical change that might, for example, stop all protein production.
Conserved sequence
A base sequence in a DNA molecule (or an amino acid sequence in a protein) that has remained essentially unchanged, and so has been conserved, throughout evolution.
Consolidation therapy
Cancer treatment given after induction therapy to consolidate the gains obtained, further reduce the number of cancer cells and achieve a complete remission. Often just called consolidation. The overall sequence of therapy may be induction, consolidation, and maintenance therapy. Induction therapy is the initial step toward reducing the number of cancer cells. Consolidation is designed to further diminish the number of cancer cells and achieve a complete remission. Maintenance is given to maintain the remission and prevent a relapse.
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