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Combinatorial joining
Combinatorial joining The joining of segments of DNA to generate essentially new genetic information, as occurs with Ig genes during the development of B cells. Combinatorial joining allows multiple opportunities for 2 sets of genes to combine in different ways.
RELATED TERMS--------------------------------------
Genetic
Hereditary. Having to do with the genes.
Genes
Basic, functional units of heredity, each occupying a specific place on a chromosome.
Development
The process of growth and differentiation.
SIMILAR TERMS--------------------------------------
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PREVIOUS AND NEXT TERMS--------------------------------------
Class switch
See isotype switch.
Classical pathway
The mechanism of complement activation initiated by antigen-antibody aggregates and proceeding by way of C1, C4 and C2.
Clonal deletion
The loss of lymphocytes of a particular specificity due to contact with either "self" or artificially introduced antigen.
Clonal selection theory
The prevalent concept that specificity and diversity of an immune response are the result of selection by antigen of specifically reactive clones from a large repertoire of preformed lymphocytes, each with individual specificities.
Cluster determinant (CD)
Cluster of antigens with which antibodies react that characterize a cell surface marker.
Combinatorial joining
Complement
A series of serum proteins involved in the mediation of immune reactions. The complement cascade is triggered classically by the interaction of antibody with specific antigen.
Complement components
An enzymatic system of serum proteins triggered by the classical and alternative pathways, and resulting in target cell lysis, phagocytosis, opsonization and chemotaxis.
Complement receptor
A structure found on erythrocytes, lymphocytes, neutrophils, monocytes and macrophages that binds C3 fragments.
Constant region
The invariant carboxyl-terminal portion of an antibody molecule, as distinct from the variable region which is at the amino-terminal of the chain.
C region
The invariant carboxyl-terminal portion of an antibody molecule, as distinct from the variable region which is at the amino-terminal of the chain.
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