Data evaluated by sorting values into various categories (for example, severe, moderate, and mild).
COMT. An enzyme that catalyzes the degradation of catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. COMT is also important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. A genetic polymorphism (a common normal variant) in COMT contributes to the responses to pain and stress.
One of the biogenic amines, including epinephrine, which is both a hormone (adrenaline) and a neurotransmitter; and dopamine, a neurotransmitter.
Abstract attitude. This is a type of thinking that includes voluntarily shifting one's mind set from a specific aspect of a situation to the general aspect; It involves keeping in mind different simultaneous aspects of a situation while grasping the essentials of the situation. It can involve breaking a situation down into its parts and isolating them voluntarily; planning ahead ideationally; and/or thinking or performing symbolically. A characteristic of many psychiatric disorders is the person's inability to assume the abstract attitude or to shift readily from the concrete to the abstract and back again as demanded by circumstances.
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Clinical nurse specialist
A registered nurse with an advanced degree in a particular area of patient care; e.g., neurosurgery clinical nurse specialist.
Irregular or abnormally slow or rapid beating of the heart.
A major artery in the neck that supplies blood to the head and brain.
Surgical removal of deposits (which cause restricted blood flow, or are the source of an embolus) in the walls of the carotid artery.
Case report form (CRF)
A printed, optical, or electronic document designed to record all of the protocol-required information to be reported to the sponsor on each trial subject.
Determining whether there is a reasonable possibility that the drug caused or contributed to an adverse event. It includes assessing temporal relationships, dechallenge/rechallenge information, association (or lack of association) with underlying disease, and the presence (or absence) of a more likely cause.
A localised area of cell death in the brain due to inadequate blood flow.
Biological timing and rhythmicity that, in humans, is characterised by cycles of approximately 24 hours. Synonym: biological clock.
Clean database (or file)
One from which errors have been eliminated and in which measurements and other values are provided in the same units.
A research study that involves the administration of a test regimen or experimental treatment (eg. a new drug or therapy), to humans to evaluate its efficacy and safety. See also phases of clinical trials.
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