Case report form (CRF)
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  Case report form (CRF)

Case report form (CRF)

   A printed, optical, or electronic document designed to record all of the protocol-required information to be reported to the sponsor on each trial subject.


Having to do with vision.

An individual, company, institution, or organisation which takes responsibility for the initiation, management, and/or financing of a clinical trial


Case-fatality proportion
The number of cases of a disease ending in death compared to the number of cases of the disease. Usually expressed as a percentage.

Case-to-infection ratio
The ratio of the number of cases of a disease compared to the number of infections with the agent that causes the disease. Also called the case-to-infection proportion.

The main protein found in milk and other dairy products.

Having a consistency like that of cottage cheese.


Capable of killing cells.

Clinical nurse specialist
A registered nurse with an advanced degree in a particular area of patient care; e.g., neurosurgery clinical nurse specialist.

Cardiac arrhythmia
Irregular or abnormally slow or rapid beating of the heart.

Carotid artery
A major artery in the neck that supplies blood to the head and brain.

Carotid endarterectomy
Surgical removal of deposits (which cause restricted blood flow, or are the source of an embolus) in the walls of the carotid artery.

Case report form (CRF)

Categorical data
Data evaluated by sorting values into various categories (for example, severe, moderate, and mild).

Casuality assessment
Determining whether there is a reasonable possibility that the drug caused or contributed to an adverse event. It includes assessing temporal relationships, dechallenge/rechallenge information, association (or lack of association) with underlying disease, and the presence (or absence) of a more likely cause.

Cerebral infarct
A localised area of cell death in the brain due to inadequate blood flow.

Circadian rhythm
Biological timing and rhythmicity that, in humans, is characterised by cycles of approximately 24 hours. Synonym: biological clock.

Clean database (or file)
One from which errors have been eliminated and in which measurements and other values are provided in the same units.

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