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Base excision repair
Base excision repair A process of DNA repair in which an altered base is excised (removed) by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is then filled in by the sequential action of DNA polymerase and DNA ligase. Abbreviated BER.
RELATED TERMS--------------------------------------
Base
A chemical compound that either donates hydroxide ions or absorbs hydrogen ions when dissolved in water. Bases and acids are referred to as opposites because the effect of an acid is to increase the hydronium ion concentration in water, whereas bases reduce this concentration. Arrhenius bases are water-soluble and always have a pH greater than 7 in solution.
Enzyme
A cellular protein whose shape allows it to hold together several other molecules in close proximity to each other. In this way, enzymes are able to induce chemical reactions in other substances with little expenditure of energy and without being changed themselves. Basically, an enzyme acts as a catalyst.
Excision
1. Surgical removal, as in the excision of a tumor. 2. The removal as if by surgery, as in base excision repair.
Sugar
A class of carbohydrates that taste sweet. Sugar is a quick and easy fuel for the body to use. Types of sugar are lactose, glucose, fructose, and sucrose.
BER
Base excision repair.
SIMILAR TERMS--------------------------------------
Base
A chemical compound that either donates hydroxide ions or absorbs hydrogen ions when dissolved in water. Bases and acids are referred to as opposites because the effect of an acid is to increase the hydronium ion concentration in water, whereas bases reduce this concentration. Arrhenius bases are water-soluble and always have a pH greater than 7 in solution.
Base (dentistry)
The dentistry sense of base is cement placed under a dental restoration to insulate the pulp (nerve chamber)
Base in DNA
A unit of the DNA. There are 4 bases: adenine (A), guanine (G), thymine (T), and cytosine (C). The sequence of bases (for example, CAG) is the genetic code.
Base of tongue
The back third of the tongue. In contrast to the anterior tongue, which is the front two-thirds of the tongue. The distinction between the anterior and base of the tongue reflects the fact that they are of different embryological origin. The distinction also matters as regards cancer. See: Tongue cancer.
Base pair
Two DNA bases complementary to one another (A and T or G and C) that join the complementary strands of DNA to form the double helix characteristic of DNA.
Base sequence
The order of the nucleotide bases -- adenine (A), thymine (T), guanine (G), and cytosine (C) -- in a DNA molecule.
Base sequence analysis
A method for determining the order of nucleotide bases in DNA.
Base, pressor
A pressor base is a substance chemically classified as a base (or amine) that is capable of raising the blood pressure.
Base-excision repair
See: Base excision repair.
Basel doctors
All doctors near Basel, Switzerland. Doctors who can assist a patient in Basel.
Baseline
1. Information gathered at the beginning of a study from which variations found in the study are measured. 2. A known value or quantity with which an unknown is compared when measured or assessed. 3. The initial time point in a clinical trial, just before a participant starts to receive the experimental treatment which is being tested. At this reference point, measurable values such as CD4 count are recorded. Safety and efficacy of a drug are often determined by monitoring changes from the baseline values.
Baseline assessment
Assessment of subjects as they enter a trial and before they receive any treatment.
Basement membrane
A thin membrane upon which is posed a single layer of cells. The basement membrane is made up of proteins held together by type IV collagen. The epithelial cells are anchored with hemidesmosome to the basement membrane. The end result resembles a layer of tiles attached to a thin sheet.
PREVIOUS AND NEXT TERMS--------------------------------------
Basal cell nevus syndrome
The Gorlin syndrome.
Basal cells
Small, round cells found in the lower part, or base, of the epidermis, the outer layer of the skin.
Basal metabolic rate
A measure of the rate of metabolism. For example, someone with an overly active thyroid will have an elevated basal metabolic rate.
Basal nuclei
"A region located at the base of the brain composed of 4 clusters of neurons, or nerve cells. This area of the brain is responsible for body movement and coordination. The groups of neurons most prominently and consistently affected in Huntington disease -- the pallidum and striatum -- are located in the basal nuclei. (The pallidum is composed of structures called the globus pallidus and the ventral pallidum while the striatum consists of the caudate nucleus, putamen, and ventral striatum.) The basal nuclei are also called the basal ganglia. The term ""basal"" refers to the location of these collections of neurons (nuclei or ganglia) deep within the brain, seemingly at its very base."
Basal thermometer
Colloquially used as a synonym for basal temperature. Any thermometer can be used to take the basal temperature, although special digital thermometers that are capable of storing and tracking basal temperatures over a period of time are available.
Base excision repair
Base in DNA
A unit of the DNA. There are 4 bases: adenine (A), guanine (G), thymine (T), and cytosine (C). The sequence of bases (for example, CAG) is the genetic code.
Base of tongue
The back third of the tongue. In contrast to the anterior tongue, which is the front two-thirds of the tongue. The distinction between the anterior and base of the tongue reflects the fact that they are of different embryological origin. The distinction also matters as regards cancer. See: Tongue cancer.
Base pair
Two DNA bases complementary to one another (A and T or G and C) that join the complementary strands of DNA to form the double helix characteristic of DNA.
Base sequence
The order of the nucleotide bases -- adenine (A), thymine (T), guanine (G), and cytosine (C) -- in a DNA molecule.
Base sequence analysis
A method for determining the order of nucleotide bases in DNA.
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