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Attenuated familial adenomatous polyposis
Attenuated familial adenomatous polyposis An inherited predisposition to colorectal cancer characterized by fewer than 100 adenomatous polyps in the colon and rectum. It is said to be attenuated because there are fewer polyps than in classic familial adenomatous polyposis (FAP). People with attenuated familial adenomatous polyposis (AFAP) also tend to be older at the diagnosis of their polyps (average age of 44 years) and cancer (average age of 56 years), 10 to 15 years later than in classic FAP. The right side of the colon tends to be involved in AFAP and rectal involvement is rare. AFAP is transmitted in an autosomal dominant manner.
RELATED TERMS--------------------------------------
Predisposition
Tendency to develop a certain disease.
Colorectal
Related to the colon and/or rectum.
Cancer
Any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream.
Polyps
An abnormal growth of a mucous membrane, often in the nasal passages, bladder, rectum, or uterus. Polyps, though often benign, have been associated with cancers and can be surgically removed.
Colon
Another name for the large intestine. The section of the large intestine extending from the cecum to the rectum. An adult colon is approximately five to six feet in length and is responsible for absorbing water and forming, storing and expelling waste.
Rectum
An 8-inch chamber connected to the large intestine that receives solid waste (feces) from the descending colon to be expelled from the body. The rectum connects the colon to the anus. It is the rectum's job to receive stool from the colon, to let the person know that there is stool to be evacuated, and to hold the stool until evacuation happens.
Attenuated
Weakened, diluted, thinned, reduced, weakened, diminished.
Familial
A condition that is tends to occur more often in family members than expected by chance alone. A familial disease may be genetic (such as cystic fibrosis) or environmental (such as tuberculosis).
Polyposis
The presence of many polyps.
Diagnosis
The determination of the presence of a specific disease or infection, usually accomplished by evaluating clinical symptoms and laboratory tests.
FAP
Familial adenomatous polyposis, a prominent hereditary colon cancer syndrome.
AFAP
Attenuated familial adenomatous polyposis.
Autosomal
"Pertaining to a chromosome that is not a sex chromosome; relating to any one of the chromosomes save the sex chromosomes. People normally have 22 pairs of autosomes (44 autosomes) in each cell together with two sex chromosomes (X and Y in the male and XX in the female). "
Dominant
A genetic trait is considered dominant if it is expressed in a person who has only one copy of that gene. (In genetic terms, a dominant trait is one that is phenotypically expressed in heterozygotes). A dominant trait is opposed to a recessive trait which is expressed only when two copies of the gene are present. (In genetic terms, a recessive trait is one that is phenotypically expressed only in homozygotes).
SIMILAR TERMS--------------------------------------
Attending or Primary Physician
The doctor who has the main responsibility for your care while you are in the hospital. There may be other doctors caring for you such as consulting doctors, resident doctors, and medical students.
Attending physician
The doctor who is primarily responsible for a patient's care.
Attention
The ability to focus in a sustained manner on a particular stimulus or activity. A disturbance in attention may be manifested by easy distractibility or difficulty in finishing tasks or in concentrating on work.
Attention deficit disorder (ADD)
An inability to control behavior due to difficulty in processing neural stimuli.
Attention deficit hyperactivity disorder
A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattention, impulsivity, and hyperactivity. Although most individuals have symptoms of both inattention and hyperactivity-impulsivity, one or the other pattern may be predominant. The disorder is more frequent in males than females. Onset is in childhood. Symptoms often attenuate during late adolescence although a minority experience the full complement of symptoms into mid-adulthood.
Attentional
Relating to attention. The term is used in psychology and child development as, for example, early television exposure has been found to be associated with attentional problems at age 7.
Attenuate
To weaken, dilute, thin, reduce, weaken, diminish.
Attenuated
Weakened, diluted, thinned, reduced, weakened, diminished.
Attenuated FAP
Attenuated familial adenomatous polyposis.
Attenuated virus
"To attenuate is to weaken or to make (or become) thin. Now ""attenuate"" refers to procedures that weaken an agent of disease (a pathogen). An attenuated virus is a weakened, less vigorous virus. A vaccine against a viral disease can be made from an attenuated, less virulent strain of the virus, a virus capable of stimulating an immune response and creating immunity but not causing illness."
PREVIOUS AND NEXT TERMS--------------------------------------
Attack, vasovagal
See: Vasovagal reaction.
Attention deficit disorder (ADD)
An inability to control behavior due to difficulty in processing neural stimuli.
Attentional
Relating to attention. The term is used in psychology and child development as, for example, early television exposure has been found to be associated with attentional problems at age 7.
Attenuate
To weaken, dilute, thin, reduce, weaken, diminish.
Attenuated
Weakened, diluted, thinned, reduced, weakened, diminished.
Attenuated familial adenomatous polyposis
Attenuated FAP
Attenuated familial adenomatous polyposis.
Attenuated virus
"To attenuate is to weaken or to make (or become) thin. Now ""attenuate"" refers to procedures that weaken an agent of disease (a pathogen). An attenuated virus is a weakened, less vigorous virus. A vaccine against a viral disease can be made from an attenuated, less virulent strain of the virus, a virus capable of stimulating an immune response and creating immunity but not causing illness."
Atypical
Not typical, not usual, not normal, abnormal. Atypical is often used to refer to the appearance of precancerous or cancerous cells.
Atypical measles syndrome (AMS)
An altered expression of measles, AMS begins suddenly with high fever, headache, cough, and abdominal pain. The rash may appear 1 to 2 days later, often beginning on the limbs. Swelling (edema) of the hands and feet may occur. Pneumonia is common and may persist for 3 months or more.
Audiogram
A test of hearing at a range of sound frequencies.
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