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Acanthosis nigricans
Acanthosis nigricans "A skin condition characterized by dark thickened velvety patches, especially in the folds of skin in the axilla (armpit), groin and back of the neck. The condition is complex. It can occur with endocrine diseases such as Cushing disease, tumors of the pituitary, and diabetes mellitus. It is common in people who have insulin resistance -- whose body is not responding correctly to the insulin that they make in their pancreas. Acanthosis nigricans also occurs with underlying malignancies (especially carcinomas of the vicera), administration of certain drugs, and as a genetic disorder inherited in an autosomal dominant manner.
RELATED TERMS--------------------------------------
Skin
Skin is an organ of the integumentary system; which is composed of a layer of tissues that protect underlying muscles and organs. Skin is used for insulation, vitamin D production, sensation, and excretion (through sweat).
Condition
The term "condition" has a number of biomedical meanings including the following: 1.An unhealthy state, such as in "this is a progressive condition." 2.A state of fitness, such as "getting into condition." 3.Something that is essential to the occurrence of something else; essentially a "precondition." 4.As a verb: to cause a change in something so that a response that was previously associated with a certain stimulus becomes associated with another stimulus; to condition a person, as in behavioral conditioning.
Axilla
The armpit
Groin
The region of the body where the thigh and lower abdomen meet.
Endocrine
Pertaining to hormones and the glands that make and secrete them into the bloodstream through which they travel to affect distant organs. The endocrine sites include the hypothalamus, pituitary gland, pineal gland, thyroid, parathyroids, heart (which makes atrial-natriuretic peptide), the stomach and intestines, islets of Langerhans in the pancreas, the adrenal glands, the kidney (which makes renin, erythropoietin, and calcitriol), fat cells (which make leptin). the testes, the ovarian follicle (estrogens) and the corpus luteum in the ovary). Endocrine is as opposed to exocrine. (The exocrine glands include the salivary glands, sweat glands and glands within the gastrointestinal tract.)
Disease
Illness or sickness often characterized by typical patient problems (symptoms) and physical findings (signs). Disruption sequence: The events that occur when a fetus that is developing normally is subjected to a destructive agent such as the rubella (German measles) virus.
Pituitary
The gland from which a number of hormones are released into the bloodstream. These hormones include growth hormone, ACTH, B-lipocortin (the precursor to B-endorphorin), FSH, LH, and TSH.
Diabetes
A condition in which blood glucose is not well controlled. Type I diabetics make no insulin, whereas type 2 diabetics are characterized by the overproduction of insulin, but the inability of the target cells to respond to the insulin.
Insulin
The hormone that drives incoming nutrients into cells for storage. Excess insulin is the primary pillar of aging.
Pancreas
A large, elongated gland located behind the lower portion of the stomach that secretes the hormones insulin and glucagon into the blood. These hormones are essential in regulating blood sugar levels. The pancreas also secretes enzymes into the small intestine that help with digestion and neutralize acid from the stomach.
Genetic
Hereditary. Having to do with the genes.
Autosomal
"Pertaining to a chromosome that is not a sex chromosome; relating to any one of the chromosomes save the sex chromosomes. People normally have 22 pairs of autosomes (44 autosomes) in each cell together with two sex chromosomes (X and Y in the male and XX in the female). "
Dominant
A genetic trait is considered dominant if it is expressed in a person who has only one copy of that gene. (In genetic terms, a dominant trait is one that is phenotypically expressed in heterozygotes). A dominant trait is opposed to a recessive trait which is expressed only when two copies of the gene are present. (In genetic terms, a recessive trait is one that is phenotypically expressed only in homozygotes).
SIMILAR TERMS--------------------------------------
Acanthamoeba
A microscopic organism, an amoeba, found in soil, dust and fresh water (lakes, rivers, hot springs and hot tubs). Acanthamoeba also occur in brackish water and sea water as well as in heating, venting, and air conditioner units, humidifiers, and dialysis units. Acanthamoeba can enter the skin through a cut, wound, or through the nostrils and, once inside the body, can travel to the lungs and through the bloodstream to other parts of the body, especially to the central nervous system (the brain and spinal cord). Through improper storage, handling, and disinfection of contact lenses, Acanthamoeba can enter the eye and there cause infection. A particularly dire infection caused by Acanthamoeba called granulomatous amebic encephalitis is characterized by headache, stiff neck, nausea, vomiting, confusion, loss of balance, seizures, and coma that can progress over several weeks and end in death. Acanthamoeba infections occur more frequently in people with compromised immune systems and the chronically ill. Eye and skin infections are generally treatable while infections of the brain are almost always fatal.
Acanthamoeba keratitis
Infection of the cornea by acanthamoeba, a microscopic water-borne ameba. The disease tends to occur in people who wear contact lens. It can accompany a bacterial infection of the eye. Acanthamoeba keratitis can produce corneal ulceration and result in severe loss of vision and even blindness. Signs and symptoms are persistent redness and pain in the eye. Treatment is with multiple antibiotics, often including antifungal drugs, and sometimes surgery after the infection has subsided.
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Abused inhalant
A breathable chemical vapor that is abused. All abused inhalants produce psychoactive (mind-altering) effects.
AC
"Abbreviation for a.c. (ante cibum on a prescription); acromioclavicular (shoulder joint); antecubital (crook of elbow).
Acanthamoeba
A microscopic organism, an amoeba, found in soil, dust and fresh water (lakes, rivers, hot springs and hot tubs). Acanthamoeba also occur in brackish water and sea water as well as in heating, venting, and air conditioner units, humidifiers, and dialysis units. Acanthamoeba can enter the skin through a cut, wound, or through the nostrils and, once inside the body, can travel to the lungs and through the bloodstream to other parts of the body, especially to the central nervous system (the brain and spinal cord). Through improper storage, handling, and disinfection of contact lenses, Acanthamoeba can enter the eye and there cause infection. A particularly dire infection caused by Acanthamoeba called granulomatous amebic encephalitis is characterized by headache, stiff neck, nausea, vomiting, confusion, loss of balance, seizures, and coma that can progress over several weeks and end in death. Acanthamoeba infections occur more frequently in people with compromised immune systems and the chronically ill. Eye and skin infections are generally treatable while infections of the brain are almost always fatal.
Acanthamoeba keratitis
Infection of the cornea by acanthamoeba, a microscopic water-borne ameba. The disease tends to occur in people who wear contact lens. It can accompany a bacterial infection of the eye. Acanthamoeba keratitis can produce corneal ulceration and result in severe loss of vision and even blindness. Signs and symptoms are persistent redness and pain in the eye. Treatment is with multiple antibiotics, often including antifungal drugs, and sometimes surgery after the infection has subsided.
Acanthosis nigricans
Acapnia
"Less than the normal level of carbon dioxide in the blood. The opposite of hypercapnia. The origin of the word ""acapnia"" is curious. It comes from the Greek ""a-"" meaning ""without"" + ""kapnos"" meaning ""smoke"" so acapnia literally means ""smokeless"" referring to carbon dioxide which is a principal part of smoke.
Acaricide
An agent, usually a chemical, that kills mites. This class of pesticides is large and includes antibiotic acaricides, carbamate acaricides, formamidine acaricides, mite growth regulators, organophosphate acaricides, and many others. From the Latin acarus, a mite + -cide, to kill.
ACC
Adenoid cystic carcinoma.
Accelerated phase of leukemia
Refers to chronic myelogenous leukemia (CML) that is progressing. The number of immature, abnormal white blood cells in the bone marrow and blood is higher than in the chronic phase but not as high as in the blast phase.
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