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   Achondrogenesis type II.


A genetic disorder of bonwe resulting in short-limbed dwarfism. There are a number of different types of achondrogenesis. See: Achondrogenesis type II.



Acetyl coenzyme A
An important metabolic intermediate, derived from various pathways, such as glycolysis, fatty acid oxidation, and degradation of some amino acids. It also represents a key intermediate in lipid biosynthesis. Commonly referred to as acetyl CoA.

Acetyl phosphate
A molecular ion which plays a role in the synthesis of the four-carbon fatty acid, butyric acid. The formula for acetyl phosphate is: CH3COPO42-.

An enzyme that breaks down the neurotransmitter acetylcholine at the synaptic cleft (the space between two nerve cells) so the next nerve impulse can be transmitted across the synaptic gap. Pesticides of the organophosphate and carbamate types act to paralyze and kill insects by inhibiting their acetylcholinesterase. Abbreviated AChE.

An antioxidant drug used to reduce the thickness of mucus and ease its removal. It is also used to reverse the toxicity of high doses of acetaminophen. Acetylcysteine with hydration significantly reduces the risk of contrast nephropathy in patients with chronic renal insufficiency. Also called N-acetyl-L-cysteine.


ACh (acetylcholine)
Abbreviation for acetylcholine. See: Acetylcholine.

"A disease of the esophagus caused by the abnormal function of nerves and muscles of the esophagus that makes swallowing difficult. There may sometimes be chest pain. Regurgitation of undigested food can occur, as can coughing or breathing problems due to entry of food into the lungs. The underlying problems are weakness of the lower portion of the esophagus and failure of the lower esophageal sphincter to open and allow passage of food. Achalasia may occur at any age but is predominantly a disease of young adults. Diagnosis is made by an X-ray, endoscopy, or esophageal manometry (to measure the pressure in the esophagus). Treatment includes medication, dilation (stretching) to widen the lower part of the esophagus, and surgery to open the lower esophagus. A fairly recent approach involves injecting medicines into the lower esophagus to relax the sphincter. The ""ch"" in achalasia is pronounced ""k"" as in ""ache"". The word achalasia comes from the Greek ""a-"", failure or absence + ""chalasis"", relaxation = a failure of relaxation, referring to failure of the lower sphincter muscle of the esophagus to relax."

AChE (acetylcholinesterase)
Abbreviation for acetylcholinesterase. See: Acetylcholinesterase.

In Greek mythology, the hero who was thought to have some special medical knowledge. Achilles studied medicine with Chiron, the centaur, who invented it.

Achilles tendon
A tough sinew that attaches the calf muscle to the back of the heel bone. The Achilles tendon is one of the longest tendons in the body. It is also called the tendo Achilles or the tendo calcaneus, the calcaneus being the heel bone.

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