AB Variant Gangliosidosis GM2
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  AB Variant Gangliosidosis GM2



AB Variant Gangliosidosis GM2

   Inherited diseases characterized by the accumulation of G(M2) GANGLIOSIDE in central nervous system lysosomes and variably in other tissues. Subtypes include TAY-SACHS DISEASE and SANDHOFF DISEASE, as well as an AB variant of BETA-N-ACETYLHEXOSAMINIDASE deficiency and an adult onset form of GM2 Gangliosidosis.

RELATED TERMS
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Diseases
A definite pathologic process with a characteristic set of signs and symptoms. It may affect the whole body or any of its parts, and its etiology, pathology, and prognosis may be known or unknown.

Central
In anatomy and medicine (as elsewhere), central is the opposite of "peripheral" which means away from the center.

DISEASE
Illness or sickness often characterized by typical patient problems (symptoms) and physical findings (signs). Disruption sequence: The events that occur when a fetus that is developing normally is subjected to a destructive agent such as the rubella (German measles) virus.

Adult
A person having attained full growth or maturity. Adults are of 19 through 44 years of age.

Gangliosidosis
A group of often fatal inherited diseases marked by the accumulation of GANGLIOSIDES in LYSOSOMES secondary to enzymatic deficiency states. Gangliosidoses include TAY- SACHS DISEASE; GANGLIOSIDOSIS GM1; GANGLIOSIDOSES GM2; and SANDHOFF DISEASE; which share the infantile or childhood onset of CENTRAL NERVOUS SYSTEM deterioration. (Menkes, Textbook of Child Neurology, 5th ed, pp89-97)



SIMILAR TERMS
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PREVIOUS AND NEXT TERMS
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Abandonment, Patient
Refusal of the health professional to initiate or continue treatment of a patient or group of patients. The refusal can be based on any reason. The concept is differentiated from PATIENT REFUSAL OF TREATMENT see TREATMENT REFUSAL which originates with the patient and not the health professional.

Abandoned Child
A child who is deserted by parents or parent substitutes without regard for its future care.

Abactrim
This drug combination has proved to be an effective therapeutic agent with broad-spectrum antibacterial activity against both gram-positive and gram-negative organisms. It is effective in the treatment of many infections, including Pneumocystis carinii pneumonia in AIDS, but is the drug of choice for urinary infection.

Abactal
A synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.

ABaC50,005
A partial adrenergic agonist with functional beta 1-receptor specificity and inotropic effect. It is effective in the treatment of acute cardiac failure, postmyocardial infarction low-output syndrome, shock, and reducing orthostatic hypotension in the Shy-Drager syndrome.

AB Variant Gangliosidosis GM2

Aarane
A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.

Abdominal Aortic Aneurysm
An aneurysm in that part of the aorta continuing from the thoracic region and giving rise to the inferior phrenic, lumbar, median sacral, mesenteric, renal, and ovarian or testicular arteries.

Abdominal Aortas
The aorta from the diaphragm to the bifurcation into the right and left common iliac arteries.

Abdominal Abscesses
An abscess located in the abdominal cavity, i.e., the cavity between the diaphragm above and the pelvis below. (From Dorland, 27th ed)

Abdomens, Acute
Clinical syndrome characterized by abdominal pain of great severity associated with other symptoms and signs, usually those of acute peritonitis, which might well be the result of a ruptured abdominal viscus or a similar abdominal catastrophe requiring urgent surgical operation.

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